骨质疏松症是一种全身代谢性疾病，双膦酸盐已被证实在提高骨密度和降低骨折风险方面 有显著疗效，是目前临床上治疗骨质疏松症的一线药物。本文将从几种常见双膦酸盐的作用机制、临床 疗效、不良反应以及药物假期等方面展开综述，以期为临床用药选择提供参考。

Osteoporosis is a systemic metabolic disease. Bisphosphonates are the first ⁃line drugs in the treatment of osteoporosis，which have been proved to have significant effects on improving bone density and reduc⁃ ing the risk of fracture. This article systematically reviewed the mechanism of action，clinical efficacy，adverse reactions and drug holiday of several bisphosphonates，which might provide useful information for future research.