目的 探讨手术干预对卵巢型子宫内膜异位症（ovarian endometriosis，OEM）患者IVF/ICSI助孕结局的影响。 方法 选取2019年1月1日至2024年2月1日期间于郑州大学第三附属医院生殖中心行IVF/ICSI治疗的OEM患者，其中助孕前未手术组228例（A组）、助孕前手术组426例（B组），分析两组的助孕结局。 结果 两组间的女方年龄、BMI、不孕年限、不孕类型、基础FSH水平、AFC均差异无统计学意义（P > 0.05）。B组的AMH水平低于A组（P = 0.003）。两组间促排卵方案的应用、Gn总天数、Gn总量均差异无统计学意义（P > 0.05），但B组的Gn启动量高于A组（P = 0.011）。运用多重线性回归调整混杂因素后，A组和B组间的2PN受精率差异有统计学意义（P = 0.007），而两组间的获卵数、可利用胚胎率、优质胚胎率、囊胚形成率均差异无统计学意义（P > 0.05）。应用二元logistic回归对临床妊娠率、活产率相关影响因素进行调整后，两组的临床妊娠率（aOR = -0.896，95%CI： 0.540 ~ 1.488）、活产率（aOR = 0.976，95%CI： 0.589 ~ 1.620）仍然差异无统计学意义。 结论 手术干预可能会进一步损伤OEM患者的卵巢储备功能，但似乎并不影响胚胎质量及妊娠结局。助孕前手术治疗可能会改善OEM患者的受精率。

Objective To investigate the effect of surgical intervention on IVF/ICSI assisted conception outcomes in patients with ovarian endometriosis （OEM）. Methods OEM patients who underwent IVF/ICSI treatment at the Reproductive Center of the Third Affiliated Hospital of Zhengzhou University between January 1， 2019 and February 1， 2024 were selected， including 228 cases in the non-operated group before assisted conception （Group A） and 426 cases in the operated group before assisted conception （Group B）， and the assisted conception outcomes of the two groups were analysed. Results There were no statistically significant differences in female age， BMI， infertility years， infertility type， and basal FSH level between the two groups （P > 0.05）. AMH level and basal AFC were higher in group A than in group B （P = 0.003）. There was no statistical difference in the application of ovulation induction programme， total number of Gn days and total amount of Gn between the two groups （P > 0.05）， but the amount of Gn initiation in Group A was lower than that in Group B （P = 0.011）. Applying multiple linear regression to adjust for confounding factors， there was a statistical difference in the 2PN fertilization rate between Groups A and B （P = 0.007）， whereas there was no statistical difference in the number of eggs obtained， the rate of available embryos， the rate of high-quality embryos and the rate of blastocyst formation between the two groups （P > 0.05）. After applying binary logistic regression to adjust for the influencing factors related to clinical pregnancy rate and live birth rate， the clinical pregnancy rate （aOR = -0.896， 95%CI： 0.540 ~ 1.488）， live birth rate in the two groups （aOR = 0.976， 95%CI： 0.589 ~ 1.620） remained statistically indistinguishable. Conclusions Surgical intervention may further impair ovarian reserve function in patients with OEM， but does not appear to affect embryo quality or pregnancy outcome. Surgical treatment prior to assisted conception may improve fertilization rates in patients with OEM.