Research progress on region⁃specific synaptic plasticity in the central nervous system involved in morphine tolerance
Received date: 2025-04-28
Online published: 2025-07-18
韩雅洁 , 王健 , 宋宗斌 . 中枢神经系统区域特异性突触可塑性参与吗啡耐受的研究进展[J]. 实用医学杂志, 2025 , 41(13) : 2100 -2104 . DOI: 10.3969/j.issn.1006-5725.2025.13.023
The repeated administration of morphine frequently gives rise to tolerance， manifested by a reduction in analgesic efficacy and an elevation in adverse effects. These consequences significantly impinge upon its clinical utility. Synaptic functional plasticity governs long-term alterations in synaptic transmission efficiency through calcium signaling pathways， protein kinase cascade reactions， and glia-neuron interactions， thereby facilitating the development of morphine tolerance. Structural plasticity encompasses the dynamic remodeling of dendritic spine density and morphology， the establishment or elimination of synaptic connections， and the reconstitution of synaptic active zones. Morphine-induced synaptic plasticity within the central nervous system demonstrates region-specific alterations， which jointly drive the process of tolerance. This review comprehensively synthesizes the research advancements regarding the mechanisms of synaptic plasticity in morphine tolerance， with the aim of furnishing a theoretical foundation for the development of innovative analgesic medications and the optimization of clinical treatment strategies.
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