目的 探讨封闭负压引流联合Ilizarov胫骨横向骨搬移术对重度糖尿病足的氧化应激、炎症反应的影响。 方法 选择2019年7月至2023年3月期间贵州医科大学第二附属医院（黔东南州第二人民医院）收治的60例重度糖尿病足患者作为研究对象，随机分为对照组（n = 30）和观察组（n = 30），对照组患者给予Ilizarov胫骨横向骨搬移术，观察组患者给予封闭负压引流联合Ilizarov胫骨横向骨搬移术。对比两组患者的缩小率、愈合率、生长因子［表皮生长因子（EGF）、转化生长因子（TGF）、血管内皮生长因子（VEGF）］、氧化应激指标［晚期蛋白氧化产物（AOPP）、丙二醛（MDA）、超氧化物歧化酶（SOD）］、炎症因子［降钙素原（PCT）、白细胞介素-18（IL-18）、C反应蛋白（CRP）］、不良反应及截肢率。 结果 观察组患者的缩小率、愈合率均高于对照组（P < 0.05）。治疗后，观察组患者的EGF、TGF及VEGF等生长因子水平改善优于对照组（P < 0.05）；观察组患者的血清AOPP、MDA及SOD水平改善优于对照组（P < 0.05）；观察组患者的血清PCT、IL-18及CRP等炎症因子水平改善优于对照组（P < 0.05）。观察组患者红肿、疼痛及出血等不良反应的发生率6.67%与对照组患者红肿、疼痛及出血等不良反应的发生率11.67%相比差异无统计学意义（P > 0.05）。观察组患者的截肢率3.33%低于对照组的23.33%（P < 0.05）。 结论 封闭负压引流联合Ilizarov胫骨横向骨搬移术对重度糖尿病足的疗效较佳，能够促进创面愈合，改善氧化应激和抑制炎症反应，降低截肢率，安全性较高，封闭负压引流联合Ilizarov胫骨横向骨搬移术治疗重度糖尿病足值得临床借鉴及推广。

Objective To investigate the impact of closed negative pressure drainage in combination with Ilizarov transverse tibial bone transport on oxidative stress and inflammatory response in patients with severe diabetic foot. Methods A total of 60 patients with severe diabetic foot who were admitted to the hospital from July 2019 to March 2023 were recruited as the research subjects. These patients were randomly allocated into a control group （n = 30） and an observation group （n = 30）. The control group received Ilizarov tibial transverse bone transport alone， whereas the observation group was treated with closed negative pressure drainage in conjunction with Ilizarov tibial transverse bone transport. The following parameters were compared between the two groups of patients： the reduction rate of wound size， the healing rate， growth factors ［Epidermal Growth Factor （EGF）， Transforming Growth Factor （TGF）， Vascular Endothelial Growth Factor （VEGF）］， oxidative stress indicators ［Advanced Protein Oxidation Products （AOPP）， Malondialdehyde （MDA）， Superoxide Dismutase （SOD）］， inflammatory factors ［Procalcitonin （PCT）， Interleukin-18 （IL-18）， C-reactive Protein （CRP）］， adverse reactions， and the amputation rate. Results The shrinkage rate and healing rate of patients in the observation group were both significantly higher than those in the control group （P < 0.05）. Post-treatment， the improvement in growth factor levels， including EGF， TGF， and VEGF， in the observation group was more pronounced compared to that in the control group （P < 0.05）. Regarding serum AOPP， MDA， and SOD levels， the improvement in the observation group was superior to that in the control group （P < 0.05）. Moreover， the improvement in inflammatory factor levels such as serum PCT， IL-18， and CRP in the observation group was more notable than that in the control group （P < 0.05）. The incidence of adverse reactions such as redness， swelling， pain， and bleeding in the observation group was 6.67%. When compared with the incidence of 11.67% in the control group， no statistically significant difference was observed （P > 0.05）. The amputation rate of patients in the observation group was 3.33%， which was significantly lower than 23.33% in the control group （P < 0.05）. Conclusions Closed negative pressure drainage combined with Ilizarov tibial transverse bone transport demonstrates better efficacy in the treatment of severe diabetic foot. This treatment modality can effectively promote wound healing， enhance oxidative stress regulation， and inhibit the inflammatory response， presenting a relatively high safety profile. Therefore， the application of closed negative pressure drainage combined with Ilizarov tibial transverse bone transport in the treatment of severe diabetic foot merits clinical reference and promotion.