目的 探讨全内镜下椎板开窗减压（full endoscopic lamina fenestration discectomy， Endo-LOVE）联合内镜下神经根射频脉冲（nerve root pulsed radiofrequency， NR-PRF）治疗腰椎退行性疾病（lumbar degenerative disease， LDD）的临床疗效，聚焦术后残留症状的改善。 方法 回顾性分析2022年1月至2023年6月在医院诊治的102例LDD患者，其中观察组（Endo-LOVE联合NR-PRF）53例，对照组（单纯Endo-LOVE）49例，平均随访时间为（15.05 ± 1.15）个月。对比两组患者一般资料，并于术前、术后1 d、7 d、1个月、3个月、6个月及末次随访时间点进行观察，比较两组围手术期临床数据及随访结果。 结果 术前两组间一般情况、临床指标（VAS、M-JOA和ODI评分）均差异无统计学意义，术后两组临床指标较术前均有明显改善（P < 0.05）。观察组术后3个月内各临床指标及术后患肢疼痛、麻木等残留症状改善均明显优于对照组（P < 0.05），术后6个月、末次随访两组间临床指标及末次随访时Macnab评分均差异无统计学意义（P > 0.05）。 结论 Endo-LOVE治疗LDD具有较高的安全性和可靠性，结合内镜下NR-PRF进一步提高了临床疗效，降低了术后残留症状的发生率，有助于术后快速康复。这种优势互补的联合为LDD提供了一种全新的治疗思路。

Objective To explore the clinical effectiveness of full endoscopic lamina fenestration discectomy （Endo-LOVE） in combination with nerve root pulsed radiofrequency （NR-PRF） in the treatment of lumbar degenerative disease （LDD）， along with the amelioration of postoperative residual symptoms. Methods A retrospective analysis was performed on 102 patients with LDD who were treated in our hospital between January 2022 and June 2023. Among them， 53 cases were assigned to the observation group （receiving Endo-LOVE combined with NR-PRF）， and 49 cases were included in the control group （undergoing Endo-LOVE alone）. The mean follow-up period was 15.05 ± 1.15 months. The general data of the two groups were compared. Observations were carried out at preoperative， 1-day， 7-day， 1-month， 3-month， 6-month， and final follow-up time points postoperatively. The perioperative data and follow-up outcomes of the two groups were compared. Results Prior to surgery， no significant disparities were detected in the general conditions and clinical observation indicators （VAS， M-JOA， and ODI scores） between the two groups. Postoperatively， both groups exhibited a notable improvement in clinical indicators when compared to the preoperative levels （P < 0.05）. Within three months after surgery， the observation group showed significantly more pronounced improvement in all clinical indicators than the control group （P < 0.05）. At six months postoperatively and during the final follow-up， no statistically significant differences in clinical indicators were found between the two groups. Moreover， at the final follow-up， there was no statistically significant difference in the Macnab scores between the two groups （P > 0.05）. Conclusion Endoscopic decompression for the treatment of LDD exhibits high safety and reliability. When combined with endoscopic NR-PRF， it enhances the clinical efficacy， reduces the incidence of postoperative residual symptoms， and facilitates rapid postoperative recovery. This complementary combination presents a novel therapeutic strategy for LDD.