收稿日期: 2025-02-16
网络出版日期: 2025-06-19
基金资助
国家自然科学基金资助项目(81972313);江苏省卫生健康委员会医学科研资助项目(X373)
Research progress of Rho GTPase activating protein for regulator of tumor cell migration
Received date: 2025-02-16
Online published: 2025-06-19
Rho GTPase激活蛋白（Rho GTPase-activating proteins， ARHGAP）是一类通过加速Rho家族GTP酶（如RhoA、Rac1、Cdc42等）结合的GTP水解反应，进而负向调控其活性的多功能调节蛋白家族。该家族成员广泛参与细胞信号转导、细胞黏附及细胞骨架动态重构等关键生物学过程，并在肿瘤进展中发挥重要调控作用。ARHGAP的表达模式和功能因癌症类型而异，同一分子在不同恶性肿瘤中可能表现出不同的表达水平和生物学作用。ARHGAP家族成员对肿瘤细胞迁移的调控作用与其特有的结构域特征密切相关，并受到多个信号通路的调控。本文旨在通过对现有研究进行综合分析和总结，分析ARHGAP各家族成员在肿瘤细胞迁移中的作用及机制，以期为癌症治疗和预防提供有效的分子标志物。
关键词： Rho GTPase激活蛋白; Rho家族GTP酶; 肿瘤; 迁移; 信号通路
陈诗涵 , 季湧 , 朱伟 . 肿瘤细胞迁移关键调节因子Rho GTPase激活蛋白研究进展[J]. 实用医学杂志, 2025 , 41(11) : 1751 -1759 . DOI: 10.3969/j.issn.1006-5725.2025.11.021
Rho GTPase-activating proteins （ARHGAP） constitute a family of multifunctional regulatory proteins that negatively regulate Rho family GTPases （e.g.， RhoA， Rac1， Cdc42） by accelerating the hydrolysis bound to these enzymes. Members of this family are extensively involved in crucial biological processes such as cellular signal transduction， adhesion， and dynamic reorganization of cytoskeleton， while also playing significant roles in tumor progression. ARHGAP expression and function vary across cancer types， with identical molecule exhibiting divergent expression levels and biological effects in various malignancies. The regulatory effects of ARHGAP family members on tumor cell migration are closely associated with their unique structural domain characteristics and are modulated by multiple signaling pathways. This paper comprehensively analyzes and summarizes existing research to explore the roles and mechanisms of ARHGAP family members in tumor cell migration， aiming to identify potential biomarkers and therapeutic targets in cancer management and prevention.
Key words： ARHGAP; Rho GTPase; tumor; migration; signaling pathway
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