3.0 T磁共振T2 mapping序列联合血清新饱食分子蛋白1水平检测在老年膝关节早期骨关节炎诊断中的应用价值
收稿日期: 2024-12-25
网络出版日期: 2025-04-30
基金资助
河北省医学科学研究课题计划项目(20241818);邢台市重点研发计划自筹项目(2020ZC316)
Application value of 3.0T magnetic resonance imaging T2 mapping sequence combined with serum nesfatin⁃1 level detection in the diagnosis of elderly knee early osteoarthritis
Received date: 2024-12-25
Online published: 2025-04-30
目的 探讨3.0 T磁共振（MRI）T2 mapping序列联合血清新饱食分子蛋白1（nesfatin-1）水平对老年膝关节早期骨关节炎（OA）的诊断价值。 方法 选取2023年5月至2024年5月医院收治的膝关节OA的97例老年患者（OA组）和52例同期老年体检者（对照组），根据X线结果将膝关节OA组分为早期组和非早期组，均接受3.0T MRI T2 mapping序列扫描检测膝关节软骨区域T2值，检测血清nesfatin-1水平，比较上述指标差异并采用ROC曲线分析其对老年膝关节早期OA的诊断价值。 结果 97例老年膝关节OA患者中，早期组35例，非早期组62例，OA组患者膝关节5个软骨区域的T2值及nesfatin-1血清均高于对照组（ P < 0.05），早期组均低于非早期组（ P < 0.05）；膝关节软骨区域T2值和血清nesfatin-1水平单独诊断早期OA的AUC在0.774 ~ 0.871范围，联合诊断的AUC为0.939。 结论 3.0 T磁共振T2 mapping序列联合血清nesfatin-1水平检测对老年膝关节早期OA具有较高的诊断价值。
关键词： 膝关节早期骨关节炎; 老年; 磁共振; T2 mapping序列; 新饱食分子蛋白1
唐利 , 巩玉荣 , 曾立叶 , 高艳芳 , 邓成哲 . 3.0 T磁共振T2 mapping序列联合血清新饱食分子蛋白1水平检测在老年膝关节早期骨关节炎诊断中的应用价值[J]. 实用医学杂志, 2025 , 41(8) : 1238 -1242 . DOI: 10.3969/j.issn.1006-5725.2025.08.022
Objective To investigate the diagnostic potential of combining 3.0T magnetic resonance imaging （MRI） T2 mapping sequences with serum nesfatin-1 levels for detecting early osteoarthritis （OA） in elderly knees. Methods 97 elderly patients with knee osteoarthritis （OA group） and 52 elderly individuals undergoing physical examinations （control group） were recruited from a hospital between May 2023 and May 2024. Based on X-ray findings， the OA group was further divided into an early-stage subgroup and a non-early-stage subgroup. All participants underwent 3.0T MRI T2 mapping sequence scans to measure the T2 values in the knee cartilage region， and serum nesfatin-1 levels were assessed. Differences in these indicators were compared between groups. Additionally， a receiver operating characteristic （ROC） curve was constructed to evaluate the diagnostic value of these parameters for early-stage knee OA in elderly individuals. Results Among 97 elderly patients with knee OA， 35 cases were classified into the early-stage group， and 62 cases were categorized into the non-early-stage group. The T2 values in five cartilage regions of the knee and serum nesfatin-1 levels were significantly higher in the OA group compared to the control group （ P < 0.05）. Moreover， these values were significantly lower in the early-stage group than in the non-early-stage group （ P < 0.05）. The areas under the curve （AUC） for diagnosing early-stage OA using T2 values in knee cartilage regions and serum nesfatin-1 levels ranged from 0.774 to 0.871. Notably， the AUC for combined diagnosis reached 0.939 （ P < 0.05）. Conclusion 3.0T MRI using the T2 mapping sequence in combination with serum nesfatin-1 level detection demonstrates high diagnostic value for early OA in elderly patients with knee involvement.
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