综述

超声微泡在甲状腺癌诊疗中的研究进展

  • 许魁 ,
  • 周军
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  • 三峡大学第二人民医院,宜昌市第二人民医院超声科 (湖北 宜昌 443099 )

收稿日期: 2024-08-26

  网络出版日期: 2025-02-19

基金资助

湖北省自然科学基金青年项目(2023AFB137);湖北省卫健委2023年医学研究成果转化项目(WJ2023ZH0031)

Research progress of ultrasound microbubbles in diagnosis and treatment of thyroid cancer

  • Kui XU ,
  • Jun. ZHOU
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  • Department of Ultrasound,the Second People′s Hospital of China Three Gorges University,Yichang 443000,Hubei,China

Received date: 2024-08-26

  Online published: 2025-02-19

摘要

超声微泡是以脂质、蛋白质、高分子材料等作为微泡壳包绕核心气体形成的囊泡。不仅可以作为造影剂,在分子水平上进行诊断并监测病理过程,也能作为非侵入性治疗方式的载体,携带药物或者基因通过血液循环到达疾病区域,从而发挥治疗效果。与传统的诊疗方式相比,超声微泡表现出巨大的潜力,以此为基础发展而来的靶向造影与治疗,可以在早期识别特定类型的肿瘤,并在增强抗肿瘤疗效的同时,通过降低化疗药物带来的全身毒性改善预后。这为甲状腺癌未来的诊治提供了全新的思路与策略。本文就超声微泡在甲状腺癌诊疗中的运用研究进行综述。

本文引用格式

许魁 , 周军 . 超声微泡在甲状腺癌诊疗中的研究进展[J]. 实用医学杂志, 2025 , 41(3) : 454 -458 . DOI: 10.3969/j.issn.1006-5725.2025.03.023

Abstract

Ultrasonic microbubbles are vesicles withgas core stabilized by a shell comprised of lipids, proteins, and polymer materials. It can be used not only as a contrast agent to diagnose the disease and monitor the pathological process at the molecular level, but also as a carrier of non-invasive treatment, carrying drugs or genes to the region of interest through blood circulation, thereby exerting therapeutic effects. Compared with traditional diagnosis and treatment methods, ultrasound microbubbles show great potential. Targeted imaging and treatment can identify specific types of tumors in the early stage, and improve the prognosis by reducing the systemic toxicity of chemotherapy drugs while enhancing the anti-tumor efficacy. This provides a new idea and strategy for future diagnosis and treatment of thyroid cancer. This article reviews the application of ultrasound microbubbles in the diagnosis and treatment of thyroid cancer.

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