目的 探讨钠离子通道阻滞剂（SCB）治疗相关的脑功能复杂网络的变化以及对执行控制功能影响的神经机制。 方法 将21例服用SCB的颞叶癫痫患者（TLE-SCB）和12例未服用SCB的颞叶癫痫患者（TLE-N）与18例健康对照（HC）一起纳入研究。完成行静息态功能磁共振成像（rs-fMRI）和注意网络测试（ANT），应用图论方法研究3组受试者脑功能复杂网络的变化，研究脑网络变化与执行功能的关系。 结果 TLE-SCB组和TLE-N组相比HC组均出现执行功能损害。脑网络拓扑属性分析结果显示，TLE-SCB组与TLE-N组相比，多个节点介数中心性降低（均Bonferroni校正，P < 0.017）；右侧杏仁核节点聚类系数、左侧枕下回局部效率都降低（t = -2.953，P = 0.006；t = -2.597，P = 0.0142）。TLE-SCB相比于HC组，多个节点介数中心性降低（均Bonferroni校正，P < 0.017）；左侧眶部额中回节点聚类系数增加（t = 2.861，P = 0.007）；左侧颞下回局部效率降低（t = -2.870，P = 0.007）。TLE-N组相比于HC组，右侧中央旁小叶介数中心性、局部效率增加（t = 2.644，P = 0.013；t = 3.464，P = 0.002）；右侧杏仁核节点聚类系数增加（t = 2.884，P = 0.007）。相关分析显示：TLE-SCB组左侧枕下回介数中心性降低与执行效率呈负相关（P = 0.045，r = -0.441）。 结论 使用SCB药物患者出现相关脑功能网络拓扑属性的改变，可能是SCB认知障碍的网络基础。左侧枕下回可能在使用SCB的癫痫患者执行控制功能损害中发挥重要作用。

Objective To investigate the changes in the complex network of brain functions associated with sodium channel blocker （SCB） treatment and the neural mechanisms underlying the effects on executive control functions. Methods Twenty-one patients with temporal lobe epilepsy taking SCB （TLE-SCB） and 12 patients with temporal lobe epilepsy not taking SCB （TLE-N） were enrolled in the study along with 18 healthy controls （HC）. Resting-state functional magnetic resonance imaging （rsfMRI） and attentional network testing （ANT） were completed， and graph theoretic methods were applied to study the changes in the complex networks of brain function in the three groups of subjects， and to investigate the relationship between changes in brain networks and executive function. Results The TLE-SCB and TLE-N groups showed executive function impairment compared to the HC group. Analysis of brain network topological properties showed that multiple node median centrality was reduced in the TLE-SCB group compared to the TLE-N group （all Bonferroni corrected， P < 0.017）； right amygdala node clustering coefficient， and local efficiency of the left suboccipital gyrus were reduced （t = -2.953， P = 0.006； t = -2.597， P = 0.0142）. The TLE-SCB compared to the HC group had decreased multiple node median centrality （all Bonferroni corrected， P < 0.017）； increased node clustering coefficients in the left orbital middle frontal gyrus （t = 2.861， P = 0.007）； and decreased localized efficiency in the left inferotemporal gyrus （t = -2.870， P = 0.007）. The TLE-N group compared to the HC group had decreased right paracentral lobule mediator centrality， local efficiency increased （t = 2.644， P = 0.013； t = 3.464， P = 0.002）； right amygdala node clustering coefficient increased （t = 2.884， P = 0.007）. Correlation analysis showed that decreased centrality of left suboccipital gyrus mediators was negatively correlated with executive efficiency in the TLE-SCB group （P = 0.045， r = -0.441）. Conclusion Patients using SCB medication showed impairment of brain functional network topological properties， with the left suboccipital gyrus as an important node； altered brain functional network topological properties may underlie the network of cognitive impairment in SCB.