糖尿病性肾小球硬化症，是一种以血管损害为主的肾小球病变，主要与人体炎症状态相 关。肠道菌群及其代谢产物可通过多种代谢途径影响肾脏病变。早期识别糖尿病肾小球硬化高危人群 可延缓糖尿病肾病进展。本文重点讨论肠道微生物群与糖尿病性肾小球硬化的关系，旨在阐明肠道菌群 及其代谢产物和糖尿病性肾小球硬化的之间相互作用，探索将外源性补充益生菌作为治疗糖尿病性肾小 球硬化的新方法。

Diabetic glomerulosclerosis is a kind of glomerular disease dominated by vascular damage， mainly related to the inflammatory state of the body. Intestinal flora and its metabolites can influence kidney disease through a variety of metabolic pathways. Early identification of high⁃risk groups of diabetic glomerulosclerosis could delay the progression of diabetic nephropathy. This article focused on the relationship between the intestinal micro⁃ biota and diabetic glomerulosclerosis，aiming to clarify the interaction between the intestinal flora and its metabo⁃ lites and diabetic glomerulosclerosis. Also，we tried to explore the use of exogenous supplementary probiotics as a new method to treat diabetic glomerulosclerosis.