目的 探讨心脏外科术后患者居家疲劳现状，分析其影响因素。 方法 采用便利抽样法，于2023年1—12月回顾性收集在南方医科大学附属广东省人民医院行心脏外科手术出院后3个月以上的200例术后患者为研究对象，采用多维疲劳量表、整体疼痛评估量表、心脏康复量表和管理慢性病6项量表对患者进行调查。 结果 心脏外科术后居家患者疲劳整体处于中等水平。逐步多元线性回归方程显示，存在心脏康复过程焦虑（β = 7.476，P = 0.001），重度疼痛（β = 11.939，P = 0.001）以及不适症状的频率（P < 0.001）显著正向预测心脏外科术后疲劳；而慢性病管理自我效能（β = -6.974，P < 0.001）显著负向预测心脏外科术后疲劳。 结论 心脏外科术后居家患者疲劳有待进一步改善，与心脏康复焦虑、疼痛、自我效能以及不适症状的频率有关。医护人员可结合相应影响因素有针对性地制定延续性干预措施，降低心脏外科术后居家患者疲劳水平并促进康复。

Objective This study aimed to explore the current status of home-based fatigue among patients after cardiac surgery and analyze its influencing factors. Methods From January 2023 to December 2023， we retrospectively collected data from 200 patients who underwent cardiac surgery and were discharged for more than 3 months from Guangdong Provincial People's Hospital. The Multidimensional Fatigue Inventory-20， Overall Pain Assessment Scale， Cardiac Rehabilitation Inventory and Self-efficacy for Managing Chronic Disease 6-Item Scale were used to assess the patients. Results Overall fatigue of patients at home after cardiac surgery was at a moderate level. A stepwise multiple linear regression analysis revealed that anxiety during cardiac rehabilitation （β = 7.476， P = 0.001）， severe pain （β = 11.939， P = 0.001）， and frequency of discomfort symptoms （P < 0.001） significantly positively predicted post-cardiac surgery fatigue， whereas self-efficacy in chronic disease management （β = -6.974， P < 0.001） significantly negatively predicted it. Conclusions Fatigue among home-based patients after cardiac surgery requires further improvement and is associated with cardiac rehabilitation anxiety， pain severity， self-efficacy， and frequency of discomfort symptoms. Healthcare providers could develop targeted continuity interventions based on these influencing factors to reduce fatigue levels and promote recovery among home-based patients after cardiac surgery.