收稿日期: 2024-06-18
网络出版日期: 2024-12-23
基金资助
国家自然科学基金项目(82371249);广东省科技计划项目(2020A0505140006);广州市神经退行性疾病诊治研究重点实验室项目(202201000005)
Exploratory study on the relationship between brain structural network changes and gut microbiota in patients with mild cognitive impairment associated with Parkinson′s disease
Received date: 2024-06-18
Online published: 2024-12-23
目的 通过神经影像学、肠道微生物学等技术探究帕金森病轻度认知障碍（PD-MCI）患者脑结构网络与肠道菌群的关系，以及其对认知功能的影响。 方法 纳入PD-MCI组29例和PD认知正常组（PD-NC）17例，收集磁共振T1加权像和弥散张量成像进行图论分析，以及粪便样本进行16s DNA分析。偏相关分析比较差异菌与差异结构网络属性以及与认知量表评分的相关性，后行中介效应分析。 结果 PD患者的Prevotellaceae菌、Alloprevotella菌和UCG-10的丰度与语言和记忆力认知域呈正相关，而UCG-010的丰度与执行功能呈负相关，肠道菌群也与多个差异脑结构网路节点特性有关；进行中介效应分析显示，Prevotellaceae菌对于逻辑记忆的影响受到右侧岛盖部额下回的节点度的调节（IE = 0.074，95%CI：0.21 ~ 0.001，P = 0.046）。 结论 PD患者差异菌的丰度、脑结构网络与MCI的相关性分析和中介效应分析发现Prevotellaceae菌可能与MCI关联的特定脑结构网络有关，提示肠道菌群可能通过脑-肠轴介导脑网络改变影响认知功能。
铁子慧 , 何培坤 , 李彦颐 , 段青蕊 , 聂坤 , 王丽娟 . 帕金森病轻度认知障碍患者脑结构网络改变与肠道菌群的关系[J]. 实用医学杂志, 2024 , 40(24) : 3438 -3445 . DOI: 10.3969/j.issn.1006-5725.2024.24.002
Objective To investigate the relationship between brain structural networks and gut microbiota in patients with mild cognitive impairment associated with Parkinson's disease （PD-MCI）， and the impact on cognitive function by neuroimaging and intestinal microbiology techniques. Methods 29 cases of patients with PD-MCI and 17 cases of PD patients with normal cognitive function （PD-NC） were enrolled. MRI T1-weighted and diffusion tensor imaging were collected for graph theory analysis， and fecal samples were analyzed using 16s DNA sequencing. Partial correlation analysis assessed relationships among differential bacteria， structural network properties， and cognitive scale scores， finally followed by mediation effect analysis. Results In PD patients， the abundance of Prevotellaceae， Alloprevotella， and UCG-10 bacteria was positively correlated with language and memory cognitive domains， while the abundance of UCG-010 showed a negative correlation with executive function. Additionally， the gut microbiota also was associated with several distinct brain structural network node characteristics. Mediation analysis indicated that Prevotellaceae's effect on logical memory was mediated by the node degree in the right opercular inferior frontal gyrus （IE = 0.074，95%CI：0.21 ~ 0.001，P = 0.046）. Conclusions PD-MCI patients showed distinct gut microbiota and brain network features compared to PD-NC patients. The association and the mediation analysis of gut microbiota with brain networks and cognitive impairment suggests a role for Prevotellaceae in brain network alterations related to MCI， highlighting the gut-brain axis's potential influence on cognition.
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