目的 探讨单次不同诱导剂量环泊酚在无痛四维子宫输卵管超声造影术中的有效性和安全性。 方法 选取120例需行无痛经阴道四维超声子宫输卵管造影作为研究对象，每组随机选取40例，单次环泊酚诱导用量分别为0.3 mg/kg（C1组）、0.5 mg/kg（C2组）和0.7 mg/kg（C3组）。观察3组患者检查前（T1）、造影剂注入期间（T2）、检查后（T3）的3个时间点相对应的心率（HR）和无创袖带动脉平均血压（MAP）、术毕清醒时间、不良反应发生率。 结果 3组患者的HR、MAP在T1、T3差异无统计学意义（P > 0.05）；C1组HR、MAP在T2比较，高于C2组，差异有统计学意义（P < 0.05），而C2组、C3组的HR、MAP在T2比较，差异无统计学意义（P > 0.05）；C2组患者术毕清醒时间短于C3组（P < 0.05），而C1组和C2组患者术毕清醒时间比较，差异无统计学意义（P > 0.05）；C2组不良反应的发生率为10.0%，低于C1组的32.5%，C3组37.5%（P < 0.05）。 结论 0.5 mg/kg环泊酚在无痛四维子宫输卵管超声造影术具有良好的镇静，清醒迅速，不良反应发生率低等优势。

Objective To investigate the efficacy and safety of a single induction dose of cyclopofol in painless four?dimensional hysterosalpingography， this study aims to assess its academic significance and adherence to Nature journal's publication standards. Methods A total of 120 patients admitted to Guangdong Reproductive Hospital between February 2022 and December 2022， requiring painless vaginal four?dimensional ultrasound hysterosalpingography， were selected as the study population. Random selection was performed with 40 patients in each group. The dosage of cyclopofol administered was 0.3 mg/kg （C1 group）， 0.5 mg/kg （C2 group）， and 0.7 mg/kg （C3 group）. Heart rate （HR）， mean arterial pressure measured non?invasively using a cuff， time to wake after surgery， and incidence of adverse reactions were observed at three time points： before examination （T1）， during contrast agent injection （T2）， and after examination （T3）. Results There were no significant differences in heart rate （HR） and mean arterial pressure （MAP） between T1 and T3 among the three groups （P > 0.05）. However， at T2， group C1 exhibited significantly higher HR and MAP compared to group C2 （P < 0.05）， while there was no statistically significant difference in HR and MAP between group C2 and C3 at T2 （P > 0.05）. The duration of wakefulness was shorter in group C2 than in group C3 （P < 0.05）， but there was no statistical significance in wakefulness duration between group C1 and C2 （P > 0.05）. The incidence of adverse reactions was lower in group C2 （10.0%） compared to both group C1 （32.5%） and group C3 （37.5%） with statistical significance （P < 0.05）. Conclusion The administration of cyclopofol at a dosage of 0.5 mg/kg exhibits notable advantages in painless four?dimensional hysterotubal ultrasonography， including effective sedation， prompt wakefulness， and a low occurrence rate of adverse reactions.