收稿日期: 2024-03-10
网络出版日期: 2024-11-19
基金资助
中国人民解放军后勤重大项目基金资助项目(AWS17J008)
Chronic cough： Current status and prospects
Received date: 2024-03-10
Online published: 2024-11-19
刘路 , 祝筱姬 , 钟玉绪 . 慢性咳嗽：现状与展望[J]. 实用医学杂志, 2024 , 40(21) : 3107 -3112 . DOI: 10.3969/j.issn.1006-5725.2024.21.023
Chronic cough （CC） is a common respiratory disorders， with prevalence rates as high as 10% ~ 20%. The burden of CC can be severe， as patients with CC experience substantial physical effects （e.g.， stress urinary incontinence， sleep disturbance， and chest pain）， psychological consequences （e.g.， frustration， anxiety， and depression）， and social impairments （e.g.， social distress/isolation and reduced quality of life）. As a result， CC is a frustrating conundrum for patients and clinicians. In this paper， combined with the new concepts of domestic and foreign literature， we expound the concept of CC， epidemiology， pathogenesis， etiological structure， clinical manifestations and auxiliary examination， diagnosis and differential diagnosis， treatment， and future prospects， etc.， for peer reference and learn from， so as to promote more in-depth related clinical research.
| 1 | DE VINCENTIS A， BALDI F， CALDERAZZO M， et al. Chronic cough in adults： recommendations from an Italian intersociety consensus［J］. Aging Clin Exp Res， 2022，34（7）：1529-1550. doi:10.1007/s40520-022-02154-4 |
| 2 | DICPINIGAITIS P V， LIM L， FARMAKIDIS C. Cough syncope［J］. Respir Med， 2014，108（2）：244-251. doi:10.1016/j.rmed.2013.10.020 |
| 3 | MORICE A H， MILLQVIST E， BELVISI M G， et al. Expert opinion on the cough hypersensitivity syndrome in respiratory medicine［J］. Eur Respir J， 2014，44（5）：1132-1148. doi:10.1183/09031936.00218613 |
| 4 | NEGRO R W DAL， MAZZOLINI M， TURCO P， et al. Cough： impact， beliefs， and expectations from a national survey［J］. Multidiscip Respir Med，2016，11：34. doi:10.1186/s40248-016-0072-1 |
| 5 | ARINZE J T， DE ROOS E W， KARIMI L， et al. Prevalence and incidence of， and risk factors for chronic cough in the adult population： The rotterdam study［J］. ERJ Open Res， 2020，6（2）：00300-2019. doi:10.1183/23120541.00300-2019 |
| 6 | CHAMBERLAIN S A， GARROD R， DOUIRI A， et al. The impact of chronic cough： A cross-sectional European survey［J］. Lung， 2015，193（3）：401-408. doi:10.1007/s00408-015-9701-2 |
| 7 | CANNING B J， MORI N， MAZZONE S B. Vagal afferent nerves regulating the cough reflex［J］. Respir Physiol Neurobiol， 2006，152（3）：223-242. doi:10.1016/j.resp.2006.03.001 |
| 8 | GRONEBERG D A， NIIMI A， DINH Q T， et al. Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough［J］. Am J Respir Crit Care Med， 2004，170（12）：1276-1280. doi:10.1164/rccm.200402-174oc |
| 9 | UNDEM B J， CHUAYCHOO B， LEE M G， et al. Subtypes of vagal afferent C-fibres in guinea-pig lungs［J］. J Physiol， 2004，556（3）：905-917. doi:10.1113/jphysiol.2003.060079 |
| 10 | 陈颖， 黄俊文， 杨淑銮， 等. 咳嗽变异性哮喘与嗜酸粒细胞性支气管炎表型与疗程研究进展［J］. 实用医学杂志， 2022，38（15）：1851-1855. doi:10.3969/j.issn.1006-5725.2022.15.001 |
| 11 | YI F， JIANG Z， LI H， et al. Small airway dysfunction in cough variant asthma： prevalence， clinical， and pathophysiological features［J］. Front Physiol， 2022，12：761622. doi:10.3389/fphys.2021.761622 |
| 12 | NIETO L， DE DIEGO A， PERPI?á M， et al. Cough reflex testing with inhaled capsaicin in the study of chronic cough［J］. Respir Med， 2003，97（4）：393-400. doi:10.1053/rmed.2002.1460 |
| 13 | TARLO S M. Lessons from occupational eosinophilic bronchitis［J］. J Allergy Clin Immunol Pract， 2021，9（2）：945-946. doi:10.1016/j.jaip.2020.10.008 |
| 14 | SIMON L M， JAQUA E E， NGUYEN V， et al. Respiratory symptom evaluation in adults： chronic cough［J］. FP Essent， 2023，528：7-11. |
| 15 | BRIGHTLING C E， BRADDING P， SYMON FA， et al. Mast-cell infiltration of airway smooth muscle in asthma［J］. Respir Med， 2007，101（5）：1045. doi:10.1016/j.rmed.2007.01.004 |
| 16 | SONG W J， WON H K， AN J， et al. Chronic cough in the elderly［J］. Pulm Pharmacol Ther， 2019，56：63-68. doi:10.1016/j.pupt.2019.03.010 |
| 17 | NGUYEN M A， BACCI E D， VERNON M， et al. Validation of a visual analog scale for assessing cough severity in patients with chronic cough［J］. Ther Adv Respir Dis， 2021，15：17534666211049743. doi:10.1177/17534666211049743 |
| 18 | MATHUR A， LIU-SHIU-CHEONG P S K， MUNRO A， et al. Chronic cough： A practical approach to assessment and management［J］. Drug Ther Bull， 2019，57（5）：74-79. doi:10.1136/dtb.2018.000014 |
| 19 | IRWIN R S， FRENCH C L， CHANG A B， et al. Classification of cough as a symptom in adults and management algorithms： CHEST guideline and expert panel report［J］. Chest， 2018，153（1）：196-209. |
| 20 | BONVINI S J， BIRRELL M A， GRACE M S， et al. Transient receptor potential cation channel， subfamily V， member 4 and airway sensory afferent activation： role of adenosine triphosphate［J］. J Allergy Clin Immunol， 2016，138（1）：249-261. doi:10.1016/j.jaci.2015.10.044 |
| 21 | YANG J， CRAWLEY B， DEHOM S， et al. Chronic refractory cough： objective improvement with aerodynamic-focused［J］. J Voice， 2021，35（2）：324.e9-324.e13. doi:10.1016/j.jvoice.2019.08.026 |
| 22 | SMITH J A， BADRI H. Cough： new pharmacology［J］. J Allergy Clin Immunol Pract， 2019，7（6）：1731-1738. doi:10.1016/j.jaip.2019.04.027 |
| 23 | THOMAS D， GIBSON P G. Gefapixant for chronic cough［J］. Lancet， 2022， 399（10328）：886-887. doi:10.1016/s0140-6736(21)02438-7 |
| 24 | SHAPIRO C O， PROSKOCIL B J， OPPEGARD L J， et al. Airway sensory nerve density is increased in chronic cough［J］. Am J Respir Crit Care Med， 2020，203（3）：348-355. doi:10.1164/rccm.201912-2347oc |
| 25 | MUCCINO D， GREEN S. Update on the clinical development of gefapixant， a P2X3 receptor antagonist for the treatment of refractory chronic cough［J］. Pulm Pharmacol Ther， 2019，56：75-78. doi:10.1016/j.pupt.2019.03.006 |
| 26 | MORICE A， SMITH J， MCGARVEY L， et al. Eliapixant （BAY 1817080）， A P2X3 receptor antagonist， in refractorychronic cough： a randomised， placebo-controlled， crossover phase 2a study［J］. Eur Respir J， 2021，58（5）： 2004240. doi:10.1183/13993003.04240-2020 |
| 27 | GARCEAU D， CHAURET N. BLU-5937： A selective P2X3 antagonist with potent anti-tussive effect and no taste alteration［J］. Pulm Pharmacol Ther， 2019，56：56-62. doi:10.1016/j.pupt.2019.03.007 |
| 28 | DICPINIGAITIS P V， MCGARVEY L P， CANNING B J. P2X3-receptor antagonists as potential antitussives： Summary of current clinical trials in chronic cough［J］. Lung， 2020，198（4）： 609-616. doi:10.1007/s00408-020-00377-8 |
| 29 | NGUYEN V， ZHANG Q， PAN F， et al. Zi-Su-Zi decoction improves airway hyperresponsiveness in cough-variant asthma rat model through PI3K/AKT1/mTOR， JAK2/STAT3 and HIF-1α/NF-κB signaling pathways［J］. J Ethnopharmacol， 2023，314：116637. doi:10.1016/j.jep.2023.116637 |
| 30 | JIANG H， BAI Z， OU Y， et al. β-Hydroxybutyric acid upregulated by Suhuang antitussive capsule ameliorates cough variant asthma through GSK3β/AMPK-Nrf2 signal axis［J］. J Ethnopharmacol， 2023，307：116013. doi:10.1016/j.jep.2022.116013 |
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