收稿日期: 2024-01-17
网络出版日期: 2024-10-22
基金资助
国家自然科学基金项目(81600844);河北省中央引导地方科技专项(236Z7709G);唐山市基础研究项目(23130217E)
Research progress on the application of platelet⁃rich fibrin in promoting bone regeneration during maxillary sinus floor lifting surgery
Received date: 2024-01-17
Online published: 2024-10-22
上颌窦底提升术是口腔种植领域用于解决上颌后牙区垂直骨量不足时常用的一种手术方式，包括上颌窦内提升术和外提升术。富血小板纤维蛋白（PRF）作为第二代血小板浓缩物，具有一定的骨诱导性，可以促进间充质干细胞的成骨分化，在上颌窦底提升术中常与骨移植材料混合使用或单独使用，具有较大的应用前景。基于目前研究现状对PRF促进上颌窦底黏膜中间充质干细胞成骨分化的分子机制尚未详细报道，同时PRF在上颌窦底提升术的应用仍然存在争议。本文根据国内外相关文献就PRF在上颌窦底提升术后促进上颌窦底黏膜中间充质干细胞成骨分化的机制以及在上颌窦底提升术中的不同应用方式进行综述，以期为临床医生合理利用PRF进行上颌窦底提升术、进一步推进PRF的临床应用提供参考依据。
谢善恩 , 张妍 , 温国琛 , 曲皓 , 董伟 . 富血小板纤维蛋白在上颌窦底提升术中促进骨再生应用方式的研究进展[J]. 实用医学杂志, 2024 , 40(19) : 2789 -2795 . DOI: 10.3969/j.issn.1006-5725.2024.19.021
Maxillary sinus floor lifting surgery is a commonly used surgical method in the field of oral implantology to solve the problem of insufficient vertical bone in the posterior maxillary area. It includes internal and external maxillary sinus lifting. Platelet-rich fibrin （PRF）， as a second-generation platelet concentrate， has certain osteoinductive properties and can promote the osteogenic differentiation of mesenchymal stem cells. In maxillary sinus floor lifting surgery， PRF is often mixed with bone grafting materials or used alone， which has great application prospects. Based on current research， the molecular mechanism of PRF promoting osteogenic differentiation of maxillary sinus mucoperiosteal has not been reported in detail， and the application of PRF in maxillary sinus floor lifting surgery is still controversial.This article reviewed the mechanism of PRF in promoting osteogenic differentiation of maxillary sinus mucoperiosteal after maxillary sinus floor lifting surgery， as well as the different application methods of PRF in maxillary sinus floor lifting surgery based on relevant literature， in order to provide a reference for clinicians to rationally use PRF in maxillary sinus floor lifting surgery and furtherly promote the clinical application of PRF.
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