收稿日期: 2024-02-25
网络出版日期: 2024-10-22
基金资助
国家自然科学基金项目(82060359);贵州省卫生健康委科学技术基金项目(gzwjkj2019-1-070)
The research progress of macrophage glycolysis in sepsis
Received date: 2024-02-25
Online published: 2024-10-22
蔡兴 , 马兴龙 , 周长健 , 谢鹏 , 沈松璇 , 缪宴梅 , 宋佳美 , 谢雷宇 . 巨噬细胞糖酵解在脓毒症中的研究进展[J]. 实用医学杂志, 2024 , 40(19) : 2783 -2788 . DOI: 10.3969/j.issn.1006-5725.2024.19.020
Sepsis is a heterogeneous syndrome. It is caused by infections， attributing to immune dysfunction pathologically. The disease is characterized by macrophage-mediated inflammation and immune response throughout its development. During septic development， macrophages metabolize crucially with glycolysis remarkably enhanced. The glycolystic enhancement facilitates septic development by promoting the inflammatory response of macrophages and altering their phenotype. Therefore， direct or indirect inhibition of macrophagic glycolysis can alleviate sepsis and neutralize damages to organs functionally， promoting the polarization of anti-inflammatory phenotype. In this review， we aim to investigate the relationship between macrophagic glycolysis and sepsis， focusing on researching into relevant molecular mechanisms by which glycolysis is regulated for treating sepsis. It is concluded that interfering with macrophagic glycolysis may serve as a novel therapeutic strategy for treating sepsis.
Key words： sepsis; macrophage; glycolysis
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