收稿日期: 2024-05-14
网络出版日期: 2024-09-30
基金资助
江苏省“双创博士”计划项目(JSSCBS?20211551);南京市卫生科技发展专项资金项目计划(YKK22240)
The pathogenesis and potential therapeutic targets of metaflammation in NAFLD
Received date: 2024-05-14
Online published: 2024-09-30
牛春燕 , 黄健康 . 代谢性炎症新概念及其与非酒精性脂肪性肝病发病机制和治疗靶点的联系[J]. 实用医学杂志, 2024 , 40(18) : 2525 -2529 . DOI: 10.3969/j.issn.1006-5725.2024.18.003
"Metaflammation，" proposed by Hotamisligil in 2006， refers to a chronic low-grade inflammation triggered by metabolic factors such as excessive nutrition and energy， persisting at subacute levels over an extended period. Immune cells infiltrate the inflammatory site， leading to enhanced expression or activity of various inflammatory molecules and subsequent inflammatory damage. Recent research on metabolic-related fatty liver disease has revealed that modern metaflammation plays a pivotal role in the pathogenesis of NAFLD. The associated inflammatory pathways offer promising prospects for the development of targeted drugs. This article provides an updated review on the advancements in metaflammation within NAFLD.
Key words： metaflammation; NAFLD; inflammatory molecules; inflammatory pathways; targeted drugs
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