目的 研究弥漫大B细胞淋巴瘤（DLBCL）中类泛素结合酶UFC1的表达及意义。方法 应用 免疫组化法检测 UFC1 在 DLBCL 的表达；应用数据库 GEPIA 和 GEO 数据集研究 UFC1 在 DLBCL 中的表达； 应用 GEO 数据集分析 UFC1 表达与 DLBCL 的临床特征的关系；应用 GEO 数据集及 OSdbl 分析 UFC1 表达与 DLBCL 预后关系；利用Linkedomics 分析UFC1共表达基因；应用String⁃DB 分析UFC1相互作用的蛋白网络。 结果 免疫组化结果显示 UFC1 在 DLBCL 中表达明显高于反应性淋巴结炎组织（P < 0.001），GEPIA 分析 显示 UFC1 在 DLBCL 表达明显高于正常组织（P＜0.01），GSE9327 数据集分析也显示 UFC1 在 DLBCL 呈高 表达（P＜0.000 1）；GSE10846 数据集分析显示 UFC1 高表达与老年（P = 0.003）、non⁃GCB 分型（P = 0.015） 相关，且高表达 UFC1 的 DLBCL 患者 OS 较短（P = 0.032 6），OSdlc 分析显示 UFC1 高表达的 DLBCL 患者 PFS （P = 0.015 9）、OS（P = 0.032 5）均较差。Linkedomics 分析显示 UFC1 与核糖体及氧化磷酸化等多种肿瘤机 制相关；String⁃DB 分析显示 UFC1 与多种肿瘤标志物存在相互作用。结论 UFC1 在 DLBCL 中表达升高， UFC1 的高表达在老年及 non⁃GCB 类型的 DLBCL 中更明显，UFC1 高表达的 DLBCL 患者可能提示预后不 良。UFC1可能成为淋巴瘤潜在治疗靶点。

Objective To study the expression and significance of UFC1 in diffuse large B cell lymphoma （DLBCL）. Methods The expression of UFC1 in DLBCL was detected by immunohistochemical method. The expression of UFC1 in DLBCL was studied by GEPIA and GEO DataSet. The relationship between UFC1 expression and the clinical characteristics of DLBCL was analyzed by GEO DataSet. The relationship between UFC1 expression and DLBCL prognosis was analyzed using GEO Dataset and OSdbl. Linkedomics was used to analyze UFC1 co⁃expressed genes. String⁃db was used to analyze the protein network of UFC1 interaction. Results Immunohisto⁃ chemical results showed that the expression of UFC1 in DLBCL was significantly higher than that of reactive lymph⁃ adentis tissue（P = 0.000），GEPIA analysis showed that the expression of UFC1 in DLBCL was significantly higher than that of normal tissue（P < 0.01），and GSE9327 Dataset analysis also showed that UFC1 was highly expressed in DLBCL（P < 0.000 1）. GSE10846 Dataset analysis showed that high expression of UFC1 was associated with old age（P = 0.003）and non ⁃GCB typing（P = 0.015），and the OS of DLBCL patients with high expression of UFC1 was shorter（P = 0.032 6），while OSdlc analysis showed that PFS（P = 0.015 9）and OS（P = 0.032 5）of DLBCL patients were poor with high expression of UFC1.Linkedomics analysis showed that UFC1 was related to ribosome and oxidative phosphorylation and other tumor mechanisms.String⁃db analysis shows that UFC1 interacts with a variety of tumor markers. Conclusion The expression of UFC1 is increased in DLBCL，and the abnormal high expression of UFC1 is more obvious in the elderly and non⁃GCB type DLBCL. The high expression of UFC1 in