目的 探究2型糖尿病（T2DM）合并慢性牙周炎（CP）患者血清富含亮氨酸α-2糖蛋白1（LRG1）、乳酸脱氢酶（LDH）与牙周指标和牙周病变程度的关系。 方法 选取2022年7月至2023年7月宁夏医科大学总医院口腔医院收治的112例T2DM合并CP患者（T2DM合并CP组），根据牙周病变程度将其分为轻度、中度和重度组；选取同期本院112例单纯CP患者（CP组），再选取112例单纯T2DM患者（T2DM组）；检测LRG1、LDH和牙周指标；Pearson法分析血清LRG1、LDH及二者与牙周指标的相关性；重度T2DM合并CP的影响因素采用多因素logistic回归分析；绘制ROC曲线分析血清LRG1、LDH对重度T2DM合并CP的诊断价值。 结果 CP组、T2DM组以及T2DM合并CP组LRG1、LDH水平依次升高（P < 0.05）。轻度、中度和重度组血清LRG1、LDH、附着丧失（AL）、牙周探诊深度（PD）、牙龈出血指标（BI）水平依次升高（P < 0.05）。根据Pearson相关性分析得知，血清LRG1与LDH呈正相关（P < 0.05），二者均与AL、PD、BI呈正相关（P < 0.05）。根据logistic回归分析得知LRG1、LDH、AL、PD、BI均为影响重度T2DM合并CP的因素（P < 0.05）。根据ROC曲线得知血清LRG1和LDH二者联合诊断重度T2DM合并CP的AUC为0.910，两者联合优于各自单独诊断（Z_{联合vs LRG1}=2.659、Z_{联合vs LDH} =2.627，P < 0.05）。 结论 LRG1、LDH在T2DM合并CP患者血清中显著升高，两者与牙周指标和牙周病变程度有关。

Objective To explore the relationship between serum leucine 2-rich glycoprotein 1 （LRG1）， lactate dehydrogenase （LDH） with periodontal indicators and periodontal lesions degree in patients with type 2 diabetes mellitus （T2DM） and chronic periodontitis （CP）. Methods 112 patients with T2DM combined with CP admitted to our hospital from July 2022 to July 2023 （T2DM combined with CP group） were selected and categorized into mild， moderate， and severe groups according to the degree of periodontal pathology； 112 patients with CP alone （CP group） were selected from our hospital during the same period， and then 112 patients with T2DM alone （T2DM group） were selected； and LRG1， LDH， and periodontal indexes were measured； Pearson method was applied to analyze the correlation between serum LRG1， LDH， and periodontal indicators. The influencing factors of severe T2DM combined with CP were analyzed using multivariate logistic regression. ROC curve was plotted to analyze the diagnostic value of serum LRG1 and LDH for severe T2DM combined with CP. Results The levels of LRG1 and LDH in the CP group， T2DM group， and T2DM combined with CP group increased sequentially （P < 0.05）. The levels of serum LRG1， LDH， AL， PD， and BI increased sequentially in the mild， moderate， and severe groups （P < 0.05）. According to Pearson correlation analysis， serum LRG1 was positively correlated with LDH （P < 0.05）. Serum LRG1 and LDH were positively correlated with AL， PD， and BI （P < 0.05）. According to logistic regression analysis， LRG1， LDH， AL， PD， and BI were all factors for severe T2DM combined with CP （P < 0.05）. According to the ROC curve， the AUC for the combined diagnosis of serum LRG1 and LDH in severe T2DM with CP was 0.910， and the combination of the two was better than their individual diagnosis （Z _{combination vs LRG1}= 2.659， Z _{combination vs LDH}=2.627， P < 0.05）. Conclusion LRG1 and LDH are greatly elevated in the serum of patients with T2DM combined with CP， and they are related to periodontal indicators and the periodontal lesions degree.