临床新进展

肾移植患者结核感染的研究进展

  • 张淑宇 ,
  • 李月红
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  • 清华大学附属北京清华长庚医院肾内科,清华大学临床医学院 (北京 102218 )
李月红,北京清华长庚医院肾内科和血液净化中心主任、主任医师、教授、博士研究生导师。主要研究方向:移植相关肾损伤、血液净化。北京医学会肾脏病分会常委、北京中西医结合学会肾病分会常委、北京医师协会肾病分会常务理事、中国研究型医院协会肾病分会委员、中国医院协会血液净化分会委员、中国医药协会肾病中药发展研究专业委员会常委等。获得科技部、首都临床特色、医管局扬帆计划、首发基金等。为《临床内科杂志》编委、《中国血液净化杂志》、《中华医学教育探索杂志》等审稿专家,发表SCI和中文核心期刊文章近百篇。牵头及参与20余项国内外多中心临床试验。

收稿日期: 2023-11-26

  网络出版日期: 2024-07-30

基金资助

首都卫生发展科研专项项目(首发2022-3-2243);北京清华长庚医院青年启动基金资助项目(12023C01002)

An overview of mycobacterium tuberculosis infection after kidney transplantation

  • Shuyu ZHANG ,
  • Yuehong. LI
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  • Department of Nephrology,Beijing Tsinghua Changgeng Hospital,Tsinghua Clinical Medical School,Tsinghua University,Beijing 102218,China

Received date: 2023-11-26

  Online published: 2024-07-30

摘要

结核是肾移植患者较为常见的机会性感染,发病率高。肾移植术后结核感染包括潜伏性结核感染、非活动性结核感染和活动性结核感染,具有影像学多样性。潜伏性结核感染临床症状不典型、筛查试验诊断率低、缺乏敏感特异性诊断方法。结核感染的肾移植患者结核感染治疗需注意治疗时长、与排异药的相互作用、药物毒性和治疗依从性。

本文引用格式

张淑宇 , 李月红 . 肾移植患者结核感染的研究进展[J]. 实用医学杂志, 2024 , 40(15) : 2047 -2050 . DOI: 10.3969/j.issn.1006-5725.2024.15.001

Abstract

Tuberculosis in kidney transplant(KT) recipients is a common opportunistic infection with higher incidence and prevalence than in the general population. Tuberculosis infection after kidney transplantation included latent tuberculosis infection, inactive tuberculosis infection and active tuberculosis infection. The following factors should be considered in the diagnosis of tuberculosis infection in KT recipients: atypical clinical presentation, association with co-infections, decreased predictive values of screening tests, diverse imaging findings and particular diagnostic methods. Regarding treatment challenges in KT recipients with tuberculosis, course of treatment, drug interaction, drug toxicity and therapeutically adherence should be considered.

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