收稿日期: 2023-08-22
网络出版日期: 2024-07-15
基金资助
国家重点研发计划项目(2018YFC1602206);广东省科技计划项目(2021B1212030014);广州市科技计划项目(202102100001)
Research progress on the regulation of intestinal flora on glioma
Received date: 2023-08-22
Online published: 2024-07-15
奚可欣 , 赵宇骐 , 谢晓婷 , 陆云涛 , 范宏英 , 何小艳 . 肠道菌群对胶质瘤的调控作用研究进展[J]. 实用医学杂志, 2024 , 40(14) : 2027 -2030 . DOI: 10.3969/j.issn.1006-5725.2024.14.021
Glioma is the most common primary tumor of the brain， accounting for 81 % of central nervous system （CNS） malignant tumors. The degree of malignancy is high， and the current treatment methods are limited. In recent years， with the in-depth study of intestinal flora and brain-gut axis， it has been found that the diversity of gut microbiota plays an important role in the regulation of glioma. The mechanism is that the intestinal flora affects the development of glioma through the role of immune regulation and metabolites. In addition， it has been confirmed that there is a certain correlation between some probiotics and glioma， which provides a new application prospect for the treatment of glioma. This paper discusses the main intestinal bacteria that regulate gliomas as well as the role and regulatory mechanisms of intestinal flora in the development of gliomas， and provides ideas for the discovery of new targets for glioma treatment and further improvement of treatment options.
Key words： intestinal flora; glioma; brain-gut axis
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