目的 探讨Solitaire支架机械取栓结合双重抗血小板治疗对急性脑梗死患者肢体功能和血管再闭塞的影响。 方法 研究选择2020年2月至2023年8月接受治疗的急性脑梗死患者为样本，共134例。根据患者术前1周是否每天规律服用阿司匹林和氯吡格雷，分为观察组（服用）和对照组（未服用），各67例。比较治疗1周后的血管再通情况，根据国立卫生研究院卒中量表（NIHSS）和简易Fugl-meyer运动功能量表（FMA）对两组患者治疗前、治疗后1 d、1周、1个月的神经损伤和肢体功能进行评估，比较两组治疗前和治疗后1个月的脑血流动力学指标［脑血管外周阻力（CVR）、平均血流量（Qmean）和平均血流速度（Vmean）］和血栓形成相关因子［血栓素B2 （TXB2 ）、正血小板α-颗粒膜糖蛋白（CD62P）、外周血6酮前列腺素F1α（6-keto-PGF1α）］，记录患者治疗3个月后血管再闭塞情况，通过logistic回归分析探讨患者血管再闭和血流动力学、血栓形成因子的关系。 结果 治疗后观察组患者的血管再通率、FMA评分、Qmean、Vmean、6-keto-PGF1α高于对照组，NIHSS评分、CVR、TXB2、CD62P比对照组降低，均差异有统计学意义（P < 0.05）。且观察组患者的血管再闭塞率低于对照组。Logistic分析显示，患者的脑血流动力学指标和血栓形成相关因子水平均会影响其血管再闭的发生（P < 0.05）。 结论 Solitaire支架机械取栓结合双重抗血小板治疗有助于急性脑梗死患者的肢体功能恢复，并降低血管再闭塞的风险。

Objective To investigate the effect of mechanical thrombectomy using Solitaire stent combined with dual antiplatelet therapy （DAPT） on limb function and vascular reocclusion in patients with acute cerebral infarction. Methods A total of 134 patients with acute cerebral infarction who received treatment in our hospital from February 2020 to August 2023 were selected as samples. According to whether the patients regularly took aspirin and clopidogrel every day one week before surgery， they were divided into observation group（taking the medications）and control group （without taking medications）， with 67 cases in each. The control group was given mechanical thrombectomy， and the observation group was treated with DAPT combined with mechanical thrombectomy. Outcomes measured included revascularization one week after treatment， and neurological and limb function assessment using NIHSS and FMA scale at baseline， 1 day， 1 week， and 1 month after treatment. Brain hemodynamics （CVR， Qmean， and Vmean） and thrombosis markers （TXB2， CD62P， and 6-keto-PGF1α） were evaluated pre-treatment and one month after treatment. Vascular reocclusion three months after treatment and its correlation with hemodynamics and thrombosis factors were analyzed. Results After treatment， higher revascularization rate， FMA score， Qmean， Vmean， and 6-keto-PGF1α level， and lower NIHSS score， CVR， TXB2， and CD62P level were found in the observation group （P < 0.05）. The incidence of vascular reocclusion was also lower in the observation group. Logistic analysis indicated that brain hemodynamic indicators and the level of thrombosis-related factors influenced vascular reocclusion occurrence （P < 0.05）. Conclusion Mechanical thrombectomy using Solitaire stent combined with DAPT helps the recovery of limb function in patients with acute cerebral infarction and reduces the risk of vascular reocclusion.