收稿日期: 2023-10-08
网络出版日期: 2024-06-14
基金资助
国家自然科学基金项目(82260418);百色市科学研究与技术开发计划项目(百科20232031)
Research progress of circrna and atherosclerotic ischemic stroke
Received date: 2023-10-08
Online published: 2024-06-14
潘春玲 , 易雪丽 , 苏丽 , 袁胜山 , 韦贵将 . 环状RNA与动脉粥样硬化性缺血性脑卒中的研究进展[J]. 实用医学杂志, 2024 , 40(12) : 1755 -1761 . DOI: 10.3969/j.issn.1006-5725.2024.12.024
Stroke is one of the main diseases endangering the health and life of the middle-aged and elderly， and in recent years it shows a younger trend.It has the characteristics of high incidence， mortality and disability rate. Atherosclerosis is the main intervention target for stroke prevention and treatment.CircRNA is highly expressed in the cerebrovascular system and plays an important regulatory role in the pathogenesis of ischemia-reperfusion and ischemic stroke.This paper reviews the mechanism of circRNA and miRNA molecular network in the pathophysiological process of atherosclerosis， ischemic stroke and ischemia-reperfusion injury， so as to provide theoretical support for the application of circRNA in gene diagnosis and drug treatment of atherosclerotic ischemic stroke.
Key words： circRNA; ischemic stroke; atherosclerotic; pathophysiological process; prognosis; biomarkers
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