目的 通过联合检测方法，寻找急性创伤性颅脑损伤（TBI）诊断更灵敏的生物标志物，为临床提供确切的诊断、治疗、监测指标。 方法 收集2022年10月至2023年6月由昆明市延安医院急诊创伤中心收住的急性TBI患者共156例，并纳入正常及骨折对照组，收集监测入组患者外周血标本，检测S100β、IL-6并收集患者入院即刻hs-CRP等临床资料，并进行统计学分析。 结果 急性TBI患者外周血S100β、IL-6、hs-CRP水平明显升高，诊断急性TBI的ROC曲线下面积分布为0.944、0.915、0.897，三个指标联合检测ROC曲线下面积高达0.975。Person相关分析发现三个指标之间呈正相关，尤其S100β和IL-6之间相关系数达0.715。二元logistic回归分析发现，S100β、IL-6、hs-CRP是急性TBI的独立危险因素。 结论 S100β、IL-6、hs-CRP联合检测可以有效提高急性TBI诊断的灵敏性，S100β与IL-6相互促进可能加重炎症机制导致的继发性颅脑损伤，尽早针对性治疗，可能改善预后。

Objective Through the combined detection method， we tried to find more sensitive biomarkers for the diagnosis of acute TBI， which might provide the exact diagnosis， treatment and monitoring indicators for the clinic. Methods A total of 156 patients with acute TBI admitted to the Emergency Traumatic Center of Yan'an Hospital of Kunming from October 2022 to June 2023 were collected and included the normal and fracture control groups. Peripheral blood samples of the enrolled patients were collected and monitored， S100β and IL-6 were tested and clinical data such as hs-CRP was collected immediately upon admission， then statistical analysisanalysis was conducted. Results Peripheral blood in patients with acute TBI， The levels of S100β， IL-6 and hs-CRP significantly increased， and the area under the ROC curve for diagnosing acute TBI was 0.944， 0.915， and 0.897. The combined detection of the three indicators showed an area under the ROC curve of up to 0.975. Person correlation analysis found a positive correlation between the three indicators， especially S100β with IL-6， The correlation coefficient between them is 0.715. Binary logistic regression analysis found that S100β， IL-6 and hs-CRP are independent risk factors for acute TBI. Conclusions The combined detection of S100β， IL-6 and hs-CRP can effectively improve the sensitivity of acute TBI diagnosis. The mutual promotion of S100β and IL-6 may aggravate the secondary craniocerebral injury caused by inflammatory mechanism， and early targeted treatment may improve the prognosis.