目的 研究广州地区鼻咽癌筛查人群中爱泼斯坦-巴尔病毒（EBV）的感染状况，并对EBV感染的影响因素进行分析。 方法 收集2021年1~12月在广州市干部和人才健康管理中心进行EBV抗体VCA-IgA和NA1-IgA检测的鼻咽癌筛查人群的资料，年龄20岁以上，了解EBV感染状况，并通过logistic回归分析其感染情况及影响因素。 结果 共收集研究对象55 311例，其中男35 429例（64.05%），女19 882例（35.95%），总体EBV感染率为8.0%，不同性别的差异无统计学意义（P > 0.05）；随着年龄增加，EBV感染率增高，20 ~ 39岁感染率7.07%，40 ~ 59岁感染率7.86%，60 ~ 79岁感染率10.11%，≥ 80岁感染率10.99%（χ² = 85.487，P < 0.01），logistic回归分析结果表明：随着年龄的增长，感染EBV的风险显著增加，40 ~ 59岁人群感染EBV的风险较20 ~ 39岁人群高10.6%（OR = 1.106，95%CI：1.028 ~ 1.190）；60 ~ 79岁人群感染EBV的风险较20 ~ 39岁人群高42.2%（OR = 1.422，95%CI：1.288 ~ 1.569）；80岁以上人群感染EBV的风险较20 ~ 39岁人群高53.1%（OR = 1.531，95%CI：1.230 ~ 1.906），有高血压病史的感染风险较无高血压者高10.5%（OR = 1.105，95%CI：1.003 ~ 1.218）；是否有糖尿病史不会显著影响EBV感染结果（P > 0.05）。 结论 广州地区EBV总体感染率为8.00%，年龄增加和高血压病史是EBV感染的危险因素，相关部门需要进一步加强EBV易感人群的筛查与防控。

Objective To study EBV infection in nasopharyngeal carcinoma screening population in Guangzhou and analyze the influencing factors. Methods The data of individuals （aged 20 years and above） having EBV antibody of VCA-IgA and NA1-IgA test in Guangzhou Cadre and Talent Health Management Centerwere collected. Current status of EBV infection was studied and its influencing factors were analyzed by logistic regression analysis. Results A total of 55 311 subjects were screened， including 35 429 males （64.05%） and 19，882 females （35.95%）.The overall EBV infection rate was 8.00%. There was no significant differences in the infection rate between different sex groups（P > 0.05）. The infection rate of EBV increased with age， with infection rate of 7.07% in individuals aged 20 ~ 39 years， 7.86% in those aged 40 ~ 59 years，10.11 % in those of 60 ~ 79 years old， and 10.99% in those aged ≥ 80 years， showing statistical significance（χ² = 85.487，P < 0.01）. Logistic regression analysis showed that EBV infection risk increased significantly with advancing age. The odds of EBV infection in individuals aged 40 ~ 59 years were 10.6% higher compared to those aged 20 ~ 39 years （OR = 1.106， 95% CI： 1.028 ~ 1.190）. The odds of EBV infection in individuals aged 60 ~ 79 years were 42.2% higher compared to those aged 20 ~ 39 years （OR = 1.422， 95% CI： 1.288 ~ 1.569）. Furthermore， the odds of EBV infection in individuals aged ≥ 80 years were 53.1% higher compared to those aged 20 ~ 39 years （OR = 1.531， 95% CI： 1.230 ~ 1.906）.A prior diagnosis of hypertension significantly increased the odds of EBV infection （OR = 1.105， 95%CI： 1.003 ~1.218）. However， diabetes history exerted no influence on the outcome of EBV infection（P > 0.05）. Conclusions The overall infection rate of EBV in Guangzhou is 8.00%. Advanced age and hypertension history are the risk factors of EBV. The screening and prevention and control of EBV susceptible people should be strengthened.