收稿日期: 2023-10-07
网络出版日期: 2024-05-21
基金资助
河北省2020年度医学科学研究课题计划(20200907)
Clinical efficacy of Niaoduqing Granule combined with Febusta in treatment of hyperuricemia with renal damage
Received date: 2023-10-07
Online published: 2024-05-21
目的 探讨尿毒清颗粒联合非布司他治疗高尿酸血症（HUA）肾损害患者临床研究。 方法 选择河北医科大学第二医院肾内科于2020年3月至2022年3月HUA肾损害患者82例，运用随机数字表法分为观察组（n = 41）与对照组（n = 41）。对照组患者采用非布司他片治疗，观察组在非布司他片基础上联合尿毒清颗粒治疗。2组疗程12周。比较2组治疗疗效，治疗前后血尿酸、肾功能、Cys C和β2-MG水平变化及不良反应情况。 结果 观察组HUA肾损害患者总有效率高于对照组（P < 0.05）。2组治疗后HUA肾损害患者血尿酸水平低于治疗前（P < 0.05）；观察组治疗后HUA肾损害患者血尿酸水平低于对照组（P < 0.05）。2组治疗后HUA肾损害患者BUN、Scr和24h Upro水平低于治疗前（P < 0.05）；观察组治疗后HUA肾损害患者BUN、Scr和24h Upro水平低于对照组（P < 0.05）。2组治疗后HUA肾损害患者Cys C和β2-MG水平低于治疗前（P < 0.05）；观察组治疗后HUA肾损害患者Cys C和β2-MG水平低于对照组（P < 0.05）。2组未出现明显不良反应。 结论 尿毒清颗粒联合非布司他治疗HUA肾损害患者疗效良好，可降低血尿酸水平及降低Cys C和β2-MG水平，对患者肾功能具有保护作用。
李娟 , 杨林 . 尿毒清颗粒联合非布司他治疗高尿酸血症肾损害患者研究[J]. 实用医学杂志, 2024 , 40(10) : 1418 -1422 . DOI: 10.3969/j.issn.1006-5725.2024.10.015
Objective To investigate the clinical efficacy of Niaoduqing Granule combined with Febusta in the treatment of renal damage in patients with hyperuricemia （HUA）. Methods Eighty-two HUA patients with renal damage in our hospital from March 2020 to March 2022 were divided into observation group （n = 41） and control group （n = 41）. The control group was treated with Febusta， while observation group with Niaoduqing granule and Febusta. Two groups were treated for 12 weeks. Blood uric acid， renal function， Cys C and β2-MG level change and adverse reactions in the two groups were compared. Results The total effective rate in the observation group was higher than in the control group （P < 0.05）. After treatment， the level of serum uric acid， BUN， Scr， 24h Upro， Cys C and β2-MG decreased in the two groups （P < 0.05）， with more significant results in the observation group （P < 0.05）. No obvious adverse reactions were observed in the two groups. Conclusion Niaoduqing Granule combined with Febusta has good effect in treating HUA patients with renal impairment. It reduces the level of blood uric acid， Cys C and β2-MG， which protect the renal function of patients，
Key words： Niaoduqing Granule; Febusta tablet; hyperuricemia; renal damage
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