收稿日期: 2023-10-21
网络出版日期: 2024-04-19
基金资助
国家自然科学基金面上项目(82274323)
Antiplatelet drugs and liver fibrosis
Received date: 2023-10-21
Online published: 2024-04-19
赵芯 , 李晖 , 邓秀秀 , 陶雨静 . 抗血小板药物与肝纤维化[J]. 实用医学杂志, 2024 , 40(8) : 1083 -1087 . DOI: 10.3969/j.issn.1006-5725.2024.08.011
The essence of hepatic fibrosis is the imbalance of the formation and degradation of extracellular matrix in the liver tissue. Hepatic fibrosis is a necessary stage for the progression of various chronic liver diseases to cirrhosis. Early inhibition of the occurrence and development of hepatic fibrosis is very important in the treatment of liver diseases. Platelets release a variety of cytokines， which promote hepatocyte proliferation and liver parenchyma regeneration while activating endothelial cells， inducing leukocyte recruitment， aggravating microvascular dysfunction， and participating in the process of liver fibrosis. In this paper， the research progress of antiplatelet drugs in hepatic fibrosis is reviewed， in order to provide new diagnosis and treatment ideas for hepatic fibrosis.
Key words： hepatic fibrosis; antiplatelet; asprin; hepatic stellate cells
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