收稿日期: 2023-08-10
网络出版日期: 2024-04-08
基金资助
安徽省高等学校科学研究重点项目(2022AH050785);合肥市2022年度第三批市关键共性技术研发项目(GJ2022SM09);合肥市第七周期医学重点学科建设专科(合卫医秘［2023］72号)
Role of complement C3 in early predicting pregnancy outcomes of frozen⁃thawed embryo transfer
Received date: 2023-08-10
Online published: 2024-04-08
目的 探讨补体C3对冻融胚胎移植（F-ET）妊娠结局的早期预测价值。 方法 前瞻性收集378个F-ET周期相关资料，依据补体C3预测F-ET妊娠结局的最佳截断值分为A组（补体C3 ≤ 1.05）120个周期；B组（补体C3 > 1.05）258个周期，比较两组结局。分析B组补体C3预测F-ET自然流产的最佳截断值。 结果 年龄是F-ET妊娠成功的危险因素（P < 0.05）；补体C3和胚胎类型是F-ET妊娠成功的保护因素（P < 0.05）。补体C3对F-ET妊娠结局的受试者工作特征曲线（ROC）曲线下面积为0.702， 最佳截断值为1.05 g/L，其预测临床妊娠灵敏度为87.60%、特异度为52.00%。B组临床妊娠率（67.05%）和胚胎着床率（52.75%）明显高于A组，差异有统计学意义（P < 0.05）。补体C3早期预测F-ET后自然流产最佳截断值为1.32 g/L，ROC曲线下面积为0.760，灵敏度为69.00%、特异度为81.20%。 结论 补体C3对早期预测F-ET妊娠结局有一定的临床意义，当补体C3超过1.32 g/L可能会导致自然流产率升高。
唐志霞 , 马双影 , 张影 , 盛佳佳 , 李娟 , 何晶晶 , 宣恒华 , 洪名云 . 补体C3水平对冻融胚胎移植妊娠结局的早期预测价值[J]. 实用医学杂志, 2024 , 40(7) : 924 -929 . DOI: 10.3969/j.issn.1006-5725.2024.07.008
Objective To investigate the role of complement C3 in early predicting pregnancy outcomes of frozen-thawed embryo transfer （F-ET）. Methods A total of 378 F-ET cycles were prospectively collected and divided into group A （complement C3 ≤ 1.05， 120 cycles） and group B （complement C3 > 1.05， 258 cycles） based on the best cutoff value of complement C3 for predicting F-ET pregnancy outcomes. The outcomes of the two groups were compared， and the best cutoff value of complement C3 for predicting F-ET spontaneous abortion was analyzed in group B. Results Age was a risk factor for successful F-ET pregnancy （P < 0.05）， and complement C3 and embryo type were protective factors for successful F-ET pregnancy （P < 0.05）. The area under the receiver-operating characteristic curve （ROC） of complement C3 for predicting F-ET pregnancy outcome was 0.702， and the best cutoff value was 1.05 g/L， with a clinical pregnancy sensitivity of 87.60% and a specificity of 52.00%. The clinical pregnancy rate and embryo implantation rate in group B were both significantly higher than those in group A （67.05% vs. 52.75%， P < 0.05）. The best cutoff value of complement C3 for predicting spontaneous abortion after F-ET was 1.32 g/L， with an area under the ROC curve of 0.760， a sensitivity of 69.00%， and a specificity of 81.20%. Conclusions Complement C3 is of significance in the early prediction of F-ET pregnancy outcome. When complement C3 exceeds the level of 1.32 g/L， it may lead to an increase in the rate of spontaneous abortion.
Key words： frozen embryo transfer; clinical pregnancy rate; complement C3
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