收稿日期: 2023-11-22
网络出版日期: 2024-04-08
基金资助
国家自然科学基金青年项目(82101683)
Mechanisms of male reproductive function damage induced by heavy metal cadmium
Received date: 2023-11-22
Online published: 2024-04-08
王联通 , 任枚琪 , 温丽琴 , 史潇 , 全松 . 重金属镉诱导雄性生殖功能损伤的机制[J]. 实用医学杂志, 2024 , 40(7) : 887 -892 . DOI: 10.3969/j.issn.1006-5725.2024.07.002
Cadmium is one of the heavy metals with severe reproductive toxicity， whose half-life lasts 20 to 40 years. Cadmium could induce dysfunction of testis and epididymis for its significant accumulation in human testis， and the amount， motility parameters and morphology of sperm change abnormally. The adverse change could also extend to male offspring and cause the impairment of their reproductive system. There has been no clear mechanism of how cadmium induces dysfunction of male reproductive system， and treatment for the adverse influence on male reproductive system by cadmium has not yet been found. Therefore， this problem has been discussed in reproductive and environmental field for a long time. A number of previous investigations showed that cadmium could damage male fertility by followed pathways， including interfering with hormone secretion， inducing oxidative stress， activating inflammation and apoptosis， and causing energy metabolism disorder， etc. In order to enlighten new ideas for therapeutic targets of male reproductive function damage induced by cadmium， we systematically reviewed and summarized the findings of previous publications in this paper.
Key words： cadmium; reproductive system; testis; epididymis; sperm
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