综述

急性呼吸窘迫综合征肺纤维化中巨噬细胞和成纤维细胞相互作用的研究进展

  • 李爱琴 ,
  • 张震 ,
  • 徐雅楠 ,
  • 朱金源 ,
  • 张旭
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  • 1.宁夏医科大学总医院,医学研究院,(银川 750004 )
    2.宁夏医科大学总医院,日间病房,(银川 750004 )
    3.宁夏医科大学总医院,老年与特需医学科,(银川 750004 )
    4.宁夏医科大学总医院,重症医学科,(银川 750004 )

收稿日期: 2023-08-24

  网络出版日期: 2024-03-08

基金资助

国家自然科学基金地区项目(82160305);宁夏自然科学基金项目(2023AAC03519)

Research progress on the interaction between macro⁃phages and fibroblasts in ARDS pulmonary fibrosis

  • Aiqin LI ,
  • Zhen ZHANG ,
  • Ya′nan XU ,
  • Jinyuan ZHU ,
  • Xu. ZHANG
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  • *.Research Institute of Medical Sciences,Department of Day Ward,General Hospital of Ningxia Medical University,Yinchuan 750004,China

Received date: 2023-08-24

  Online published: 2024-03-08

摘要

急性呼吸窘迫综合征(acute respimtory distress syndrome,ARDS)主要是由于各种肺内外损伤因素所导致的急性弥漫性炎症性肺损伤。其发病机制复杂,起病急且病死率高,严重危害人类生命健康。肺纤维化是ARDS发生发展的重要病理过程之一,是导致ARDS患者死亡的重要原因。ARDS中肺纤维化的严重程度一定程度上由巨噬细胞-成纤维细胞相互作用的动态平衡决定。因此,本文旨在综述巨噬细胞-成纤维细胞在ARDS肺纤维化过程中相互作用的机制,为ARDS肺纤维化的诊疗提供新的方法和思路。

本文引用格式

李爱琴 , 张震 , 徐雅楠 , 朱金源 , 张旭 . 急性呼吸窘迫综合征肺纤维化中巨噬细胞和成纤维细胞相互作用的研究进展[J]. 实用医学杂志, 2024 , 40(4) : 571 -574 . DOI: 10.3969/j.issn.1006-5725.2024.04.023

Abstract

Acute respimtory distress syndrome (ARDS) is an acute diffuse inflammatory lung injury caused by various internal and external lung injury factors. It has complex pathogenesis, rapid onset and high mortality, which seriously endangers human life and health. Pulmonary fibrosis is one of the important pathologic processes of ARDS occurrence and development, and it is also an important cause of death in ARDS patients. To a certain extent, the severity of pulmonary fibrosis in ARDS is determined by the dynamic balance of macrophage-fibroblast interactions. Therefore, this article aims to review the interaction mechanism of macrophage-fibroblasts in the process of ARDS pulmonary fibrosis, and provide new methods and ideas for the diagnosis and treatment of ARDS pulmonary fibrosis.

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