收稿日期: 2023-08-10
网络出版日期: 2024-03-06
基金资助
国家自然科学基金(81960361);广东省医学科研基金(B2023238)
Research progress on the relationship between m6A methylation modification and acute kidney injury
Received date: 2023-08-10
Online published: 2024-03-06
唐立丽 , 王昕宇 , 张杰 , 赵悦 , 李小悦 . m6A甲基化修饰在急性肾损伤中的研究进展[J]. 实用医学杂志, 2024 , 40(2) : 278 -282 . DOI: 10.3969/j.issn.1006-5725.2024.02.026
Acute kidney injury（AKI） is a global public health problem with high morbidity， high mortality and costly treatment cost. The pathogenesis of AKI is very complex， and the treatment strategies for AKI are limited， then it is very matter to explore the pathophysiological mechanism and potential therapeutic targets of acute kidney injury. N6-methyladenosine（m6A） is the most abundant and extremely conservative epigenetic modification in eukaryotic， which is a dynamic and reversible process involving in splicing， nuclear export， translation， stability， and higher structure of RNA， and regulated by three regulatory factors： methyltransferase， demethylase and methylated reading protein. Current studies have found that m6A plays an important regulatory role in AKI and can be a potential therapeutic target for AKI. In this review， we provide a brief description of m6A and summarize the impact of m6A on AKI and possible future study directions for this research.
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