临床研究

床旁膈肌超声在预测胸腔镜肺叶切除术后肺部并发症中的应用价值

  • 郭高锋 ,
  • 阮孝国 ,
  • 王洋洋 ,
  • 张加强
展开
  • 河南省人民医院麻醉与围术期医学科 (郑州 450003 )

收稿日期: 2023-10-07

  网络出版日期: 2024-03-06

基金资助

河南省中青年卫生健康科技创新领军人才培养项目(YXKC2020001)

Predictive value of bedside diaphragmatic ultrasound for pulmonary complications after thoracoscopic lobectomy

  • Gaofeng GUO ,
  • Xiaoguo RUAN ,
  • Yangyang WANG ,
  • Jiaqiang. ZHANG
Expand
  • Department of Anesthesiology and Perioperative Medicin,He′nan Provincial People′s Hospital,Zhengzhou 450003,China

Received date: 2023-10-07

  Online published: 2024-03-06

摘要

目的 评估床旁膈肌超声在预测胸腔镜肺叶切除术后肺部并发症(PPCs)中的应用价值。 方法 收集河南省人民医院择期行胸腔镜肺叶切除术患者,记录一般资料、围术期相关指标;术前,术后1、3、5 d床旁超声检测膈肌活动度(DE1d、DE3d、DE5d)。根据是否发生PPCs将患者分为两组(PPCs组和非PPCs组)。将单变量分析中有统计学差异的参数纳入多变量logistic回归分析中,筛选PPCs的独立影响因素。绘制受试者工作曲线(ROC),并通过曲线下面积(AUC)评估膈肌超声预测PPCs的效能。 结果 共纳入患者934例,其中537例发生PPCs(57.5%)。单因素分析显示:与非PPCs组比较,PPCs组糖尿病患者占比、术后24 h活动VAS评分增加;胸管拔除时间、单肺通气时间、术后住院时间长;PPCs组患者术后DE1d、3d手术侧、健侧;DE5d手术侧DE值低(P < 0.05)。多因素logistic回归分析显示:单肺通气时间延长、糖尿病、术后(DE1d、3d)手术侧、健侧和DE5d手术侧DE值降低是发生PPCs的独立危险因素。ROC曲线显示:术后DE1d、3d的手术侧、健侧预测PPCs的效能较高(AUC分别为0.797、0.821、0.933、0.929);术后DE5d手术侧、健测预测PPCs效能较弱(AUC分别为0.703、0.512)。 结论 术后相应时间DE降低、单肺通气时间延长、糖尿病是胸腔镜肺叶切除术后发生PPCs的独立危险因素,术后3 d应用床旁超声评价DE对PPCs具有较高的预测价值。

本文引用格式

郭高锋 , 阮孝国 , 王洋洋 , 张加强 . 床旁膈肌超声在预测胸腔镜肺叶切除术后肺部并发症中的应用价值[J]. 实用医学杂志, 2024 , 40(2) : 207 -212 . DOI: 10.3969/j.issn.1006-5725.2024.02.014

Abstract

Objective To assess the predictive value of bedside diaphragmatic ultrasound in predicting pulmonary complications (PPCs) after thoracoscopic lobectomy. Methods The patients who had undergone elective thoracoscopic lobectomy in Henan Provincial People's Hospital were collected. General information and perioperative indicators were recorded. Diaphragmatic motility was detected by bedside ultrasound preoperatively and on postoperative days 1, 3, and 5. The patients were divided into two groups (PPCs group and non?PPCs group). Statistically different parameters in univariate analysis were included in multivariate logistic regression analysis to screen independent influencing factors of PPCs. Receiver operating curve (ROC) was drawn, and the performance of diaphragm ultrasound for predicting PPCs was evaluated by the area under the curve (AUC). Results 949 patients were included in this study. PPCs occurred in 537 patients (57.5%). Univariate analysis showed that as compared with the non?PPCs group, the proportion of diabetic patients and postoperative VAS score in the PPCs group increased, time to chest tube removal and one?lung ventilation, and postoperative hospital stay were longer. PPCs group had a lower DE value on the operative side and healthy side on postoperative days 1 and 3 and on the operative side alone on day 5 (P < 0.05). Multivariate logistic regression analysis showed that prolonged one?lung ventilation time, diabetes mellitus, DE values on the operative side and unoperative side on postoperative days 1 and 3, and decreased DE value on the operative side on day 5 were independent risk factors for PPCs. The ROC curve shows that the efficacy of DE for predicting PPCs on the operative and healthy sides on postoperative days 1 and 3 was relatively high (AUC of 0.797, 0.821, 0.933, and 0.929; respectively). The efficacy of DE for predicting PPCs on the operative side was poor on postoperative day 5 (AUC of 0.703 and 0.512, respectively). Conclusions A decrease in postoperative DE, prolonged one?lung ventilation time, and diabetes are independent risk factors for PPCs after thoracoscopic lobectomy. Bedside ultrasound evaluation of DE has a higher value in predicting PPCs three days after surgery.

参考文献

1 CUI Z, ZHANG Y, XU C, et al. Comparison of the results of two chest tube managements during an enhanced recovery program after video-assisted thoracoscopic lobectomy:A randomized trial[J].Thorac Cancer, 2019,10(10):1993-1999. doi:10.1111/1759-7714.13183
2 FERNANDES E O, TEIXEIRA C, SILVA L C. Thoracic surgery: risk factors for postoperative complications of lung resection[J]. Rev Assoc Med Bras (1992), 2011,57(3):292-298. doi:10.1590/s0104-42302011000300011
3 YAO H Y, LIU T J, LAI H C. Risk factors for intraoperative hypoxemia during monopulmonary ventilation: an observational study[J]. Braz J Anesthesiol, 2019,69(4):390-395. doi:10.1016/j.bjane.2019.04.009
4 PAGANO A, NUMIS F G, VISONE G, et al. Lung ultrasound for diagnosis of pneumonia in emergency department[J]. Intern Emerg Med, 2015,10(7):851-854. doi:10.1007/s11739-015-1297-2
5 CORTELLARO F, COLOMBO S, COEN D, et al. Lung ultrasound is an accurate diagnostic tool for the diagnosis of pneumonia in the emergency department[J]. Emerg Med J, 2012,29(1):19-23. doi:10.1136/emj.2010.101584
6 ALJIBALI A S. Ultrasound utilization in the diagnosis of diaphragm dysfunction compared to other modalities: A retrospective study[J]. Int J Health Sci (Qassim), 2023,17(3):11-17.
7 DANIEL M, LANG E, HUYNH T M, et al. Prevalence and time-course of diaphragmatic dysfunction following lung resection: A repeated ultrasonic assessment[J]. Anaesth Crit Care Pain Med,2022,41(2):101024. doi:10.1016/j.accpm.2022.101024
8 CHEN Y, ZHOU S, LIAO L, et al. Diaphragmatic ultrasound can help evaluate pulmonary dysfunction in patients with stroke[J]. Front Neurol,2023,14:1061003. doi:10.3389/fneur.2023.1061003
9 FAYSSOIL A, MANSENCAL N, NGUYEN L S, et al. Diaphragm Ultrasound in Cardiac Surgery: State of the Art[J]. Medicines (Basel), 2022,9(1):5. doi:10.3390/medicines9010005
10 SANTANA P V, CARDENAS L Z, ALBUQUERQUE A L P. Diaphragm Ultrasound in Critically Ill Patients on Mechanical Ventilation-Evolving Concepts[J]. Diagnostics (Basel), 2023,13(6):1116. doi:10.3390/diagnostics13061116
11 BOSCOLO A, SELLA N, PETTENUZZO T, et al. Diaphragm dysfunction predicts weaning outcome after bilateral lung transplant[J]. Anesthesiology, 2024,140(1):126-136. doi:10.1097/aln.0000000000004729
12 ZHU Z, LI J, YANG D, et al. Ultrasonography of Diaphragm Can Predict Pulmonary Function in Spinal Cord Injury Patients: A Pilot Case-Control Study[J]. Med Sci Monit, 2019,25:5369-5374. doi:10.12659/msm.917992
13 李明秋,郭瑞君,张谱,等. M型超声观察膈肌运动与肺功能的相关性研究[J]. 首都医科大学学报, 2014,35(2):189-193. doi:10.3969/j.issn.1006-7795.2014.02.010
14 陈丹丹,方婷婷,丁怡,等. 胸腔镜肺叶切除术老年患者术前衰弱与术后肺部并发症的关系[J]. 中华麻醉学杂志, 2021,41(8):928-932. doi:10.3760/cma.j.cn131073.20210618.00808
15 KARALAPILLAI D, WEINBERG L, PEYTON P, et al. Effect of Intraoperative Low Tidal Volume vs Conventional Tidal Volume on Postoperative Pulmonary Complications in Patients Undergoing Major Surgery: A Randomized Clinical Trial[J]. JAMA,2020,324(9):848-858. doi:10.1001/jama.2020.12866
16 陈颖,易杰. 膈肌超声在麻醉管理中的应用进展[J]. 中国医学科学院学报, 2022,44(5):891-898.
17 刘杰,王涛,姜丽华,等. 膈肌超声指导小儿腹股沟疝修补术拔除喉罩时机的效果分析[J]. 实用医学杂志, 2023,39(16):2085-2089. doi:10.3969/j.issn.1006-5725.2023.16.012
18 SKLAR M C, DRES M, FAN E, et al. Association of Low Baseline Diaphragm Muscle Mass With Prolonged Mechanical Ventilation and Mortality Among Critically Ill Adults[J]. JAMA Netw Open, 2020,3(2):e1921520. doi:10.1001/jamanetworkopen.2019.21520
19 LAGHLAM D, NAUDIN C, SROUR A, et al. Persistent diaphragm dysfunction after cardiac surgery is associated with adverse respiratory outcomes: a prospective observational ultrasound study[J]. Can J Anaesth, 2023,70(2):228-236. doi:10.1007/s12630-022-02360-8
20 SPADARO S, GRASSO S, DRES M, et al. Point of Care Ultrasound to Identify Diaphragmatic Dysfunction after Thoracic Surgery[J]. Anesthesiology, 2019,131(2):266-278. doi:10.1097/aln.0000000000002774
21 TAKAHASHI Y, MORISAWA T, OKAMOTO H, et al. Diaphragm Dysfunction and ICU-Acquired Weakness in Septic Shock Patients with or without Mechanical Ventilation: A Pilot Prospective Observational Study[J]. J Clin Med, 2023,12(16):5191. doi:10.3390/jcm12165191
22 ZHANG W, CONG X, ZHANG L, et al. Effects of thoracic nerve block on perioperative lung injury, immune function, and recovery after thoracic surgery[J]. Clin Transl Med, 2020,10(3):e38. doi:10.1002/ctm2.38
23 HOLLERAN T J, NAPOLITANO M A, DUGGAN J P, et al. Predictors of 30-Day Pulmonary Complications after Video-Assisted Thoracoscopic Surgery Lobectomy[J]. Thorac Cardiovasc Surg,2023,71(4):327-335. doi:10.1055/s-0042-1748025
24 WANG Y, GONG C, YU F, et al. Effect of dexmedetomidine on intrapulmonary shunt in patients with sevoflurane maintained during one-lung ventilation: A case-control study[J]. Medicine (Baltimore), 2022,101(46):e31818. doi:10.1097/md.0000000000031818
文章导航

/