收稿日期: 2023-07-31
网络出版日期: 2024-02-22
基金资助
广东省自然科学基金项目(2020A1515010044)
Effects of Diosmine on semen quality and sex hormone concentration in patients with spermatovenous ligation
Received date: 2023-07-31
Online published: 2024-02-22
目的 研究地奥司明对精索静脉高位结扎术后患者精液质量及性激素浓度的影响。 方法 回顾性收集了中国人民解放军南部战区总医院2019年1月至2022年1月收治的精索静脉曲张患者的临床资料，根据是否有术后地奥司明服用史分为对照组和研究组。应用倾向性评分匹配法对两组患者的临床资料进行匹配，比较匹配后两组患者术前、术后3个月和术后6个月的精子质量和性激素检验指标。 结果 对照组与研究组各有73例患者匹配成功。两组患者在年龄、BMI、精液量、睾酮等指标上均保持平衡（P > 0.05）。术后3个月及术后6个月，两组患者精子总活力、前向运动率和睾酮均升高，精子畸形率、精子DNA碎片指数、促卵泡激素和促黄体生成素均降低，差异有统计学意义（P < 0.05）。在精子总活力、前向运动率、睾酮、精子畸形率、精子DNA碎片指数、促卵泡激素和促黄体生成素等检查结果中，研究组均优于对照组，差异有统计学意义（P < 0.05）。 结论 地奥司明有助于精索静脉曲张患者在精索静脉高位结扎术后精液质量的恢复及性激素浓度的改善。
王凯强 , 曹智 , 王尉 , 杨成林 , 杨悦 , 张惠芬 , 张小明 . 地奥司明对精索静脉高位结扎术后患者精液质量及性激素浓度的影响[J]. 实用医学杂志, 2024 , 40(3) : 389 -393 . DOI: 10.3969/j.issn.1006-5725.2024.03.019
Objective To investigate the effect of diosmine on semen quality and sex hormone concentration in patients with spermatovenous ligation. Methods Clinical data were retrospectively collected from January 2019 to January 2022 on patients with varicocele admitted to Department of Urology， General Hospital of Southern Theater Command， divided into a control group and a study group based on whether they had a history of Diosmine use after surgery. Clinical data from both groups were matched using propensity score matching. Sperm quality and sex hormone tests were then compared before surgery， three months after surgery and six months after surgery. Results There were 73 in the control group and 73 in the study group. Both groups were balanced in terms of age， BMI， seminal fluid volume and testosterone （P > 0.05）. Sperm motility， forward motility and testosterone were all increased 3 and 6 months after surgery， and sperm malformations， sperm DNA fragment index， follicle stimulating hormone and luteinizing hormone were all reduced significantly （P < 0.05）. The results were also better than those in the control group for total sperm motility， forward motility， testosterone， sperm DNA fragment index， follicle stimulating hormone and luteinizing hormone （P < 0.05）. Conclusions Diosmine can help to restore semen quality and improve sex hormone concentration in patients with varicocele after Laparoscopic varicocelectomy.
Key words： varicocele; semen quality; laparoscopic varicocelectomy; diosmine
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