Effect of individualized PEEP regulated by driving pressure on infant one⁃lung ventilation during thoracic surgery
Received date: 2023-02-27
Online published: 2024-02-22
目的 探讨基于驱动压(Pd)个体化调节呼气末正压(PEEP)的保护性通气策略在婴儿单肺通气(OLV)中的临床效果。 方法 60例择期胸腔镜手术婴儿随机分成对照组(C组)和驱动压力组(DP组),每组30例。于OLV期间,比较两组婴儿人工气胸前(T0)、人工气胸后10 min(T1)、人工气胸后30 min(T2)、人工气胸后60 min(T3)和人工气胸结束(T4)时的MAP、HR、潮气量(Vt)、PEEP、Pd、气道峰压(Ppeak),肺静态顺应性(Cs),以及人工气胸前后的动脉血气分析结果。 结果 两组患儿在各时间点上的MAP、HR和Vt均差异无统计学意义(P > 0.05)。与T0相比,两组患儿在T1、T2和T3时的Pd和Ppeak均升高,Cs降低(P < 0.05),在T2时的PaO2和OI降低,PaCO2 升高(P < 0.05)。与C组相比,DP组在T1、T2和T3时的Pd和Ppeak更低,PEEP和Cs更高(P < 0.05),在T2时PaO2和OI更高(P < 0.05),PaCO2 和FiO2无明显差异(P > 0.05)。OLV期间,DP组需要通气补救2例(6.9%)低于C组9例(32.4%)(P < 0.05)。两组患儿术后并发症差异无统计学意义(P > 0.05)。 结论 基于驱动压的肺保护性通气策略可个体优化婴儿OLV中PEEP设置,改善通气侧肺部顺应性和氧合。
黄伟坚 , 李洋 , 王海彦 , 刘晶 , 罗辉 , 胡祖荣 . 基于驱动压的肺保护性通气策略在婴儿单肺通气中的应用效果[J]. 实用医学杂志, 2024 , 40(3) : 360 -364 . DOI: 10.3969/j.issn.1006-5725.2024.03.014
Objective To explore the effect of protective ventilation strategies based on individualized positive end expiratory pressure (PEEP) regulated by driving pressure (Pd) in infants under OLV. Methods Sixty infants undergoing elective thoracoscopic surgery were randomly divided into the control group and driving pressure group, with 30 cases in each group. The two groups were compared in terms of MAP, HR, tidal volume (Vt), PEEP, Pd, airway peak pressure (Ppeak), and static lung compliance (Cs), and arterial blood gas during OLV before the artificial pneumothorax (T0), 10 min (T1), 30 min (T2), and 60 min (T3) after the artificial pneumothorax, and right at the end of the artificial pneumothorax (T4). Results There were no significant differences in MAP, HR, and Vt between the two groups at all the time points (P > 0.05). Both groups showed the increase in Pd and Ppeak and decresase in Cs at T1, T2, and T3 (all P < 0.05). PaO2 and OI in both group were decreased and PaCO2 was increased at T2 (all P < 0.05). Compared with the control group, the driving pressure group presented lower Pd and Ppeak, higher PEEP and Cs at T1, T2, and T3 (P < 0.05), and higher PaO2 and OI (P < 0.05) and no significant differences in PaCO2 and FiO2 at T2 (P < 0.05). The rate of rescue ventilation during OLV was lower in the driving pressure group (2 cases) than in the control group (9 cases) (6.9% versus 32.4%, P < 0.05). There was no significant difference in the incidence of postoperative complications between the two groups (P < 0.05). Conclusion The individualized positive end expiratory pressure (PEEP) regulated by Pd can optimize the PEEP settings upon infant individuals under OLV and improve the compliance and oxygenation of ventilated lung.
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