收稿日期: 2023-07-04
网络出版日期: 2024-01-10
基金资助
吉林省科技发展计划项目(20191102025YY)
The effect of modified ginseng and schisandra decoction on the efficacy and inflammatory indicators of children with lobar pneumonia （lung spleen deficiency syndrome） caused by mycoplasma pneumonia infection
Received date: 2023-07-04
Online published: 2024-01-10
目的 探讨人参五味子汤加减对肺炎支原体感染致大叶性肺炎（肺脾气虚证）患儿的临床疗效及炎症指标的改善作用。 方法 选取2020年1月至2022年7月吉林省中医药科学院第一临床医院收治的84例支原体感染致大叶性肺炎（肺脾气虚证）患儿，利用随机数字表法分为两组各42例。常规组按照传统治疗方案进行治疗，联合组在传统治疗方案基础上加用人参五味子汤加减进行治疗。7 d后比较两组患儿的中医证候积分、临床疗效、炎症指标、总不良反应发生率差异。 结果 联合组治疗后的中医证候积分、炎症指标低于常规组（P < 0.05），临床疗效等级分布优于常规组（P < 0.05），总有效率高于常规组（P < 0.05），总不良反应发生率与常规组无差异（P > 0.05）。 结论 在肺炎支原体感染致大叶性肺炎（肺脾气虚证）患儿治疗中人参五味子汤加减疗效肯定、安全性好，值得推广。
尤士军 , 梁雪 , 王春莲 , 宋钰涵 . 人参五味子汤加减对肺炎支原体感染致大叶性肺炎（肺脾气虚证）患儿的疗效及炎症指标的影响[J]. 实用医学杂志, 2023 , 39(24) : 3281 -3285 . DOI: 10.3969/j.issn.1006-5725.2023.24.023
Objective To explore the clinical efficacy of ginseng schisandra decoction in children with lobar pneumonia （lung spleen deficiency syndrome） induced by mycoplasma pneumoniae infection and improvement of inflammatory indicators. Method 84 children with lobar pneumonia （lung spleen deficiency syndrome） caused by mycoplasma infection admitted to the First Clinical Hospital of Jilin Academy of Traditional Chinese Medicine from January 2020 to July 2022 were selected and randomly divided into two groups with 42 cases each. The conventional group was treated according to the traditional treatment plan， while the combined group was treated with ginseng and schisandra decoction in addition to the traditional treatment plan. After 7 days， compare the differences in traditional Chinese medicine syndrome scores， clinical efficacy， inflammatory indicators， and total incidence of adverse reactions between the two groups of children. Result The results showed that the traditional Chinese medicine syndrome score and inflammatory indicators in the combined group were lower than those in the conventional group （P < 0.05）， and the clinical efficacy level distribution was better than that in the conventional group （P < 0.05）. The total effective rate was higher than that in the conventional group （P < 0.05）， and there was no difference in the total incidence of adverse reactions between the two groups （P > 0.05）. Conclusion In the treatment of children with lobar pneumonia （lung spleen deficiency syndrome） caused by Mycoplasma pneumoniae infection， the modified Ginseng Wuweizi decoction has a positive therapeutic effect and good safety， and is worth promoting.
| 1 | 张春玲，杨远见，刘畅，等. 血清降钙素原、肝素结合蛋白、白细胞介素?6联合序贯器官衰竭评分对重症肺炎患者预后评估的意义［J］. 实用医学杂志，2022，38（2）：168-172. |
| 2 | KUMAR S， ROY R D， SETHI G R， et al. Mycoplasma pneumoniae infection and asthma in children［J］. Trop Doct， 2019， 49（2）：117-119. |
| 3 | OKUMURA T， KAWADA J I， TANAKA M， et al. Comparison of high-dose and low-dose corticosteroid therapy for refractory Mycoplasma pneumoniae pneumonia in children［J］. J Infect Chemother， 2019， 25（5）：346-350. |
| 4 | 彭研献， 周娅微， 董晓斐. 人参五味子汤加减治疗小儿哮喘缓解期效果及对免疫功能的影响［J］. 中国医药科学， 2021， 11（3）：97-99. |
| 5 | 祝海波， 周苗苗， 杨顼， 等. 中医调治方案在儿童肺炎恢复期（肺脾气虚证，阴虚肺热症）中的疗效研究［J］. 辽宁中医杂志， 2020， 47（10）：86-89. |
| 6 | 祝志朋， 田新磊， 赵文锦， 等. 加味参蓍补脾汤联合阿奇霉素对恢复期肺脾气虚证支原体肺炎患者的临床疗效［J］. 中成药， 2021， 43（3）： 643-648. |
| 7 | 郑筱萸. 中药新药临床研究指导原则（试行）［M］. 北京：中国医药科技出版社， 2002：81-82， 85-86. |
| 8 | 张梦思， 吴文华， 李文. 调肺运脾推拿法治疗肺炎支原体感染后慢性咳嗽（肺脾气虚证）的临床研究［J］. 上海中医药杂志， 2021， 55（9）：64-67. |
| 9 | TSAI T A， TSAI C K， KUO K C， et al. Rational stepwise approach for Mycoplasma pneumoniae pneumonia in children［J］. J Microbiol Immunol Infect， 2021， 54（4）：557-565. |
| 10 | KUTTY P K， JAIN S， TAYLOR T H， et al. Mycoplasma pneumoniae Among Children Hospitalized With Community-acquired Pneumonia［J］. Clin Infect Dis， 2019， 68（1）：5-12. |
| 11 | LI Z， FEIYUE Z， GAOFENG L. Traditional Chinese medicine and lung cancer-From theory to practice［J］. Biomed Pharmacother， 2021，13（7）：111381. |
| 12 | PEI H， MA L， CAO Y， et al. Traditional Chinese Medicine for Alzheimer's Disease and Other Cognitive Impairment： A Review［J］. Am J Chin Med， 2020， 48（3）：487-511. |
| 13 | GUAN Z， ZHAO Q， HUANG Q， et al. Modified Renshen Wumei Decoction Alleviates Intestinal Barrier Destruction in Rats with Diarrhea［J］. J Microbiol Biotechnol， 2021， 31（9）：1295-1304. |
| 14 | TIAN Y， ZHONG W， ZHANG Y， et al. Baihu Jia Renshen Decoction for type 2 diabetic mellitus： A protocol for systematic review and meta-analysis［J］. Medicine （Baltimore）， 2020， 99（19）：e20210. |
| 15 | LI S， WU Z， LE W. Traditional Chinese medicine for dementia［J］. Alzheimers Dement， 2021， 17（6）：1066-1071. |
| 16 | HUANG Y， NI N， HONG Y， et al. Progress in Traditional Chinese Medicine for the Treatment of Migraine［J］. Am J Chin Med， 2020， 48（8）：1731-1748. |
| 17 | FU R， LI J， YU H， et al. The Yin and Yang of traditional Chinese and Western medicine［J］. Med Res Rev， 2021， 41（6）：3182-3200. |
| 18 | WANG X， SHI Y， XU L， et al. Traditional Chinese medicine prescription Guizhi Fuling Pills in the treatment of endometriosis［J］. Int J Med Sci， 2021， 18（11）：2401-2408. |
| 19 | FIORANELLI M， ROCCIA M G， FLAVIN D， et al. Regulation of Inflammatory Reaction in Health and Disease［J］. Int J Mol Sci， 2021， 22（10）：5277. |
| 20 | STATE N. CRP and the Prognosis of Patients with Cirrhosis［J］. Maedica （Bucur）， 2021， 16（3）：353-361. |
| 21 | WIEDEMANN S J， TRIMIGLIOZZI K， DROR E， et al. The cephalic phase of insulin release is modulated by IL-1β［J］. Cell Metab， 2022， 34（7）：991-1003. |
| 22 | DUBIN C， DEL DUCA E， GUTTMAN-YASSKY E. The IL-4， IL-13 and IL-31 pathways in atopic dermatitis［J］. Expert Rev Clin Immunol， 2021， 17（8）：835-852. |
| 23 | WU P， WANG J. Changes and Significance of Serum sB7-H3 and Cytokines in Children with Mycoplasma pneumonae Pneumonia［J］. J Coll Physicians Surg Pak， 2020， 30（3）：268-271. |
| 24 | MORENO-PéREZ G F， GONZáLEZ-TRUJANO M E， HERNANDEZ-LEON A， et al. Antihyperalgesic and Antiallodynic Effects of Amarisolide A and Salvia amarissima Ortega in Experimental Fibromyalgia-Type Pain［J］. Metabolites， 2022，13（1）：59. |
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