临床新进展

长链非编码RNA H19在中枢神经系统疾病的研究进展

  • 毛元元 ,
  • 袁静静
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  • 郑州大学第一附属医院麻醉与围术期医学部 (郑州 450000 )
袁静静,博士、副主任医师、副教授、硕士研究生导师。河南省医学会麻醉学分会第四届青年委员会主任委员;中国药理学会麻醉药理专业委员会青年委员;中国研究型医院学会麻醉学专业委员会青年委员;河南省医学会麻醉学会小儿学组委员;河南省中西医结合学会麻醉学分会委员;河南医师协会麻醉学会秘书;河南省小儿麻醉与围术期医学专业联盟委员会委员;《国际麻醉学与复苏杂志》第四届编委会青年委员;《郑州大学学报(医学版)》青年编委。

收稿日期: 2023-04-23

  网络出版日期: 2024-01-08

基金资助

国家自然科学基金项目(82101298);河南省自然科学基金项目(212300410239)

Research advances of long noncoding RNA H19 in central nervous system diseases

  • Yuanyuan MAO ,
  • Jingjing. YUAN
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  • Department of Anesthesiology,Pain and Perioperative Medicine,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China

Received date: 2023-04-23

  Online published: 2024-01-08

摘要

中枢神经系统是一个与麻醉密切相关的复杂系统,许多中枢神经系统疾病的分子生物学机制并不十分清楚。长链非编码RNA(long noncoding RNA, lncRNA) H19在人脑内含量丰富且在多种中枢神经系统疾病中发挥调控作用。同时lncRNA H19也参与调控多种麻醉药物对机体的作用。本文就lncRNA H19在中枢神经系统常见疾病的研究进展进行综述,并结合其在麻醉药物中的研究深入讨论,为进一步探索lncRNA H19在中枢神经系统的作用提供理论依据。

本文引用格式

毛元元 , 袁静静 . 长链非编码RNA H19在中枢神经系统疾病的研究进展[J]. 实用医学杂志, 2023 , 39(23) : 3021 -3026 . DOI: 10.3969/j.issn.1006-5725.2023.23.001

Abstract

Central nervous system(CNS)is a complex system closely related to anesthesiology. The molecular biological mechanisms of many CNS diseases were not exactly clear. Long noncoding RNA(lncRNA) H19 is abundant in human brain and plays an important role in the regulation of various CNS diseases. Besides, lncRNA H19 is also involved in the mechanism of several anesthetics. In this review, we emphasized the role and addressed the specific mechanisms of lncRNA H19 in CNS diseases and anesthetics, hoping to provide a new theoretical basis for future researches.

参考文献

1 CUEVAS-DIAZ DURAN R, WEI H, KIM D H,et al. Long non-coding RNAs: important regulators in the development, function and disorders of the central nervous system[J]. Neuropathol Appl Neurobiol,2019,45(6):538-556.
2 BRIDGES M C, DAULAGALA A C, KOURTIDIS A. LNCcation: lncRNA localization and function[J]. J Cell Biol,2021,220(2):e202009045.
3 WANG B, SUEN C W, MA H, et al. The Roles of H19 in Regulating Inflammation and Aging[J]. Front Immunol,2020,11:579687.
4 白建杰,林春水,叶慧瑾,等. 丙泊酚下调H19抑制乳腺癌MDA-MB-231细胞的迁移和侵袭[J]. 南方医科大学学报,2016,36(9):1255-1259.
5 GE Y, LIN D, CUI B,et al. Effects of long noncoding RNA H19 on isoflurane-induced cognitive dysregulation by promoting neuroinflammation[J]. Neuroimmunomodulation,2022,29(2):117-127.
6 GABORY A, JAMMES H, DANDOLO L. The H19 locus: role of an imprinted non-coding RNA in growth and development[J]. Bioessays, 2010,32(6):473-480.
7 HASHEMI M, MOOSAVI M S, AVED H M,et al. Long non-coding RNA (lncRNA) H19 in human cancer: From proliferation and metastasis to therapy[J]. Pharmacol Res,2022,184:106418.
8 汪乐新,刘超,马天龙,等. LncRNA H19调控肾小球足细胞焦亡中作用[J]. 实用医学杂志,2023,39(1):12-20.
9 BI Y, WANG Y, SUN X. Recent Advances of LncRNA H19 in Diabetes LncRNA H19 in Diabetes[J]. Horm Metab Res,2022,54(4):212-219.
10 HERNáNDEZ-AGUILAR A I, LUCIANO-VILLA C A, TELLO-FLORES V A,et al. Dysregulation of lncRNA-H19 in cardiometabolic diseases and the molecular mechanism involved: a systematic review[J]. Expert Rev Mol Diagn,2021,21(8):809-821.
11 ZHANG Y Y, BAO H L, DONG L X,et al. Silenced lncRNA H19 and up-regulated microRNA-129 accelerates viability and restrains apoptosis of PC12 cells induced by Aβ25-35 in a cellular model of Alzheimer's disease[J]. Cell Cycle,2021,20(1):112-125.
12 KRAUS T F J, HAIDER M, SPANNER J,et al. Altered Long Noncoding RNA Expression Precedes the Course of Parkinson's Disease-a Preliminary Report[J]. Mol Neurobiol,2017,54(4):2869-2877.
13 HAN S, REN M, KUANG T,et al. Cerebellar Long Noncoding RNA Expression Profile in a Niemann-Pick C Disease Mouse Model[J]. Mol Neurobiol,2021,58(11):5826-5836.
14 贾玉梅,朱才丰,杨坤,等. 艾灸督脉对APP/PS1双转基因小鼠mTOR/TFEB通路介导的自噬溶酶体功能及lncRNA H19表达的影响[J]. 针刺研究,2022,47(8):665-672.
15 ZHANG Y, XIA Q, LIN J. LncRNA H19 Attenuates Apoptosis in MPTP-Induced Parkinson's Disease Through Regulating miR-585-3p/PIK3R3[J]. Neurochem Res,2020,45(7):1700-1710.
16 JIANG J, PIAO X, HU S,et al. LncRNA H19 diminishes dopaminergic neuron loss by mediating microRNA-301b-3p in Parkinson's disease via the HPRT1-mediated Wnt/β-catenin signaling pathway[J]. Aging (Albany NY),2020,12(10):8820-8836.
17 NI W F, WU A M, LI Q L,et al. Induced human bone marrow stromal cells differentiate into neural cells by bFGF and cocultured with olfactory ensheathing cells[J]. Curr Stem Cell Res Ther,2014,9(4):291-296.
18 WU A M, NI W F, HUANG Z Y, et al. Analysis of differentially expressed lncRNAs in differentiation of bone marrow stem cells into neural cells[J]. J Neurol Sci,2015,351(1/2):160-167.
19 ZHU R, LIU X, HE Z. Long non-coding RNA H19 and MALAT1 gene variants in patients with ischemic stroke in a northern Chinese Han population[J]. Mol Brain,2018,11(1):58.
20 HUANG J, YANG J, LI J,et al. Association of long noncoding RNA H19 polymorphisms with the susceptibility and clinical features of ischemic stroke in southern Chinese Han population[J]. Metab Brain Dis,2019,34(4):1011-1021.
21 REZAEI M, MOKHTARI M J, BAYAT M,et al. Long non-coding RNA H19 expression and functional polymorphism rs217727 are linked to increased ischemic stroke risk[J]. BMC Neurol,2021,21(1):54.
22 LI H, TANG C, WANG D. LncRNA H19 promotes inflammatory response induced by cerebral ischemia-reperfusion injury through regulating the miR-138-5p-p65 axis[J]. Biochem Cell Biol,2020,98(4):525-536.
23 WANG J, CAO B, SUN R,et al. Exosome-transported Long Non-coding Ribonucleic Acid H19 Induces Blood-brain Barrier Disruption in Cerebral Ischemic Stroke Via the H19/micro Ribonucleic Acid-18a/Vascular Endothelial Growth factor Axis[J]. Neuroscience, 2022,500:41-51.
24 LI G, MA X, ZHAO H,et al. Long non-coding RNA H19 promotes leukocyte inflammation in ischemic stroke by targeting the miR-29b/C1QTNF6 axis[J]. CNS Neurosci Ther,2022,28(6):953-963.
25 WANG J, ZHAO H, FAN Z,et al. Long Noncoding RNA H19 Promotes Neuroinflammation in Ischemic Stroke by Driving Histone Deacetylase 1-Dependent M1 Microglial Polarization [J]. Stroke,2017,48(8):2211-2221.
26 FAN B, PAN W, WANG X,et al. Long noncoding RNA mediates stroke-induced neurogenesis[J]. Stem Cells,2020,38(8):973-985.
27 WANG J, CAO B, GAO Y,et al. Long Non-Coding RNA H19 positively associates with aspirin resistance in the patients of cerebral ischemic stroke[J]. Front Pharmacol,2020,11:580783.
28 LI Y, ZHANG Y, WALAYAT A,et al. The regulatory role of H19/miR-181a/ATG5 signaling in perinatal nicotine exposure-induced development of neonatal brain hypoxic-ischemic sensitive phenotype[J]. Int J Mol Sci,2022,23(13):6885.
29 ZHU H, WANG L, CHEN J,et al. Mechanisms underlying abnormal expression of lncRNA H19 in neonatal hypoxic-ischemic encephalopathy[J]. Am J Perinatol,2022,39(8):844-852.
30 KIM J M, MOON J, YU J S,et al. Altered long noncoding RNA profile after intracerebral hemorrhage[J]. Ann Clin Transl Neurol, 2019,6(10):2014-2025.
31 MAO S, HUANG H, CHEN X. LncRNA H19 aggravates brain injury in rats following experimental intracerebral hemorrhage via NF-κB Pathway[J]. Comput Math Methods Med,2022,2022:3017312.
32 CHEN B, WANG H, LV C,et al. Long non-coding RNA H19 protects against intracerebral hemorrhage injuries via regulating microRNA-106b-5p/acyl-CoA synthetase long chain family member 4 axis[J]. Bioengineered,2021,12(1):4004-4015.
33 袁敏,王素洁,李茜,等. LncRNA H19/Sirt3介导自噬在脑出血后损伤中的作用机制[J]. 实用医学杂志,2022,38(10):1213-1219.
34 YANG S, TANG W, HE Y,et al. Long non-coding RNA and microRNA-675/let-7a mediates the protective effect of melatonin against early brain injury after subarachnoid hemorrhage via targeting TP53 and neural growth factor[J]. Cell Death Dis,2018,9(2):99.
35 WU Z R, YAN L, LIU Y T,et al. Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumors[J]. Nat Commun,2018,9(1):4624.
36 ZHANG Y, LIU Y T, TANG H,et al. Exosome-Transmitted lncRNA H19 Inhibits the Growth of Pituitary Adenoma[J]. J Clin Endocrinol Metab,2019,104(12):6345-6356.
37 WU Z, ZHENG Y, XIE W,et al. The long noncoding RNA-H19/miRNA-93a/ATG7 axis regulates the sensitivity of pituitary adenomas to dopamine agonists[J]. Mol Cell Endocrinol,2020,518:111033.
38 ZHANG T, WANG Y R, ZENG F,et al. LncRNA H19 is overexpressed in glioma tissue, is negatively associated with patient survival, and promotes tumor growth through its derivative miR-675[J]. Eur Rev Med Pharmacol Sci,2016,20(23):4891-4897.
39 ZHENG Y, LU X, XU L,et al. MicroRNA-675 promotes glioma cell proliferation and motility by negatively regulating retinoblastoma 1[J]. Hum Pathol,2017,69:63-71.
40 WU W, HU Q, NIE E,et al. Hypoxia induces H19 expression through direct and indirect Hif-1α activity, promoting oncogenic effects in glioblastoma[J]. Sci Rep,2017,7:45029.
41 GUANG N, WANG R, GUO W S,et al. Long non-coding RNA H19 regulates the development of gliomas through the Wnt/β- catenin signaling pathway[J]. Eur Rev Med Pharmacol Sci,2019,23(10):4243-4253.
42 ZHAO W, LIN X, HAN H,et al. Long noncoding RNA H19 contributes to the proliferation and autophagy of glioma cells through mTOR/ULK1 pathway[J]. Neuroreport,2021,32(5):352-358.
43 LIU P, HUANG X, WU H,et al. LncRNA-H19 gene plays a significant role in regulating glioma cell function[J]. Mol Genet Genomic Med,2021,9(10):e1480.
44 DUAN S, LI M, WANG Z,et al. H19 induced by oxidative stress confers temozolomide resistance in human glioma cells via activating NF-κB signaling[J]. Onco Targets Ther,2018,11:6395-6404.
45 SHEN L, XU M, WANG Z,et al. Prognostic evaluation of serum long non-coding RNA H19 for endoscopic keyhole surgery or craniotomy in glioma[J]. Ann Clin Biochem,2020,57(5):365-372.
46 HAN C L, GE M, LIU Y P,et al. Long non-coding RNA H19 contributes to apoptosis of hippocampal neurons by inhibiting let-7b in a rat model of temporal lobe epilepsy[J]. Cell Death Dis,2018,9(6):617.
47 HAN C L, LIU Y P, GUO C J,et al. The lncRNA H19 binding to let-7b promotes hippocampal glial cell activation and epileptic seizures by targeting Stat3 in a rat model of temporal lobe epilepsy[J]. Cell Prolif,2020,53(8): e12856.
48 JU H, YANG Z. H19 silencing decreases kainic acid-induced hippocampus neuron injury via activating the PI3K/AKT pathway via the H19/miR-206 axis[J]. Exp Brain Res,2022,240(7/8):2109-2120.
49 HAN C L, GE M, LIU Y P,et al. LncRNA H19 contributes to hippocampal glial cell activation via JAK/STAT signaling in a rat model of temporal lobe epilepsy[J]. J Neuroinflammation,2018,15(1):103.
50 XIE Y, WANG M, SHAO Y,et al. LncRNA H19 Regulates P-glycoprotein Expression Through the NF-κB Signaling Pathway in the Model of Status Epilepticus[J]. Neurochem Res,2023,48(3):929-941.
51 IWASAKI H, SAKAI A, MARUYAMA M,et al. Increased H19 long non-coding RNA expression in schwann cells in peripheral neuropathic pain[J]. J Nippon Med Sch,2019,86(4):215-221.
52 MENG L, ZHANG Y, HE X,et al. LncRNA H19 modulates neuropathic pain through miR-141/GLI2 axis in chronic constriction injury (CCI) rats[J]. Transpl Immunol,2022,71:101526.
53 谢玉海,朵海珍,王学军. 利多卡因通过LncRNA H19/miR-671-5p分子轴调控胃癌细胞增殖,迁移及侵袭[J]. 中国免疫学杂志,2022,38(12):1475-1479.
54 ZHANG X, FU Q, XU L,et al. Dexmedetomidine postconditioning alleviates hypoxia/reoxygenation injury in senescent myocardial cells by regulating lncRNA H19 and m6A modification[J]. Oxid Med Cell Longev, 2020,2020:7059751.
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