收稿日期: 2023-07-24
网络出版日期: 2023-12-11
基金资助
河北省财政厅资助临床医学优秀人才项目基金(［2020］23号)
Clinical research progress of bexagliflozin： A new hypoglycemic drug
Received date: 2023-07-24
Online published: 2023-12-11
杨燕 , 王珍 , 王德峰 . 新型降糖药物贝格列净的临床研究进展[J]. 实用医学杂志, 2023 , 39(22) : 3015 -3020 . DOI: 10.3969/j.issn.1006-5725.2023.22.028
Several drugs have been developed for the treatment of diabetes， but many patients still fail to achieve ideal glycemic control. In January 2023， the U.S. Food and Drug Administration （FDA） approved the marketing of the sodium-glucose cotransporter 2 inhibitor， bexagliflozin， for use to improve glycemic control in adults with type 2 diabetes as an adjunctive therapy to diet and exercise. The drug has been shown to be effective and safe in the treatment of diabetes mellitus. Several clinical studies have demonstrated its efficacy and safety in type 2 diabetes， and it also has potential applications in the treatment of obesity， cardiovascular disease， and chronic kidney disease. This article summarizes the mechanism of action， clinical studies， efficacy and safety of bexagliflozin to provide reference for its clinical application in China.
Key words： type 2 diabetes mellitus; bexagliflozin; SGLT-2; review
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