收稿日期: 2023-07-24
网络出版日期: 2023-12-11
基金资助
国家自然科学基金项目(81600126)
Research progress on the application of transcriptomics technology in the diagnosis and treatment of acute leukemia
Received date: 2023-07-24
Online published: 2023-12-11
近年来转录组学技术飞速发展，利用该技术对急性白血病（acute leukemia，AL）的转录组进行分析，能够客观准确地检测AL细胞中的异常基因和功能变化，对深入揭示AL发生发展的分子机制具有重要意义。RNA测序（RNA-sequencing，RNA-seq）技术即转录组测序技术，不仅能够识别出新的致癌基因融合和特征分子标志物，对AL进行更准确的分类和风险评估，还可以针对识别出的异常基因或细胞亚群，采用对应的靶向治疗方案以改善AL患者的预后。此外，转录组学技术与其他组学技术联用，能够从不同层次监测AL的多元组学变化，更全面地解析AL发生发展的分子机制。随着RNA-seq技术的不断应用，将为AL治疗提供新的精准靶点和临床策略。
强晓 , 耿贝贝 , 刘四喜 , 夏婷 . 转录组学技术在急性白血病诊治中的应用研究进展[J]. 实用医学杂志, 2023 , 39(22) : 3010 -3014 . DOI: 10.3969/j.issn.1006-5725.2023.22.027
Transcriptomics technology has been developed rapidly in recent years. It can perform transcriptome analysis of acute leukemia （AL）， and objectively and accurately detect abnormal genes and functional changes in AL cells， which is of great significance to further reveal the molecular mechanism of AL occurrence and development. RNA?sequencing （RNA?seq） technology is transcriptome sequencing technology. It not only can identify new oncogene fusions and characteristic molecular markers for more accurate classification and risk assessment of AL but also detect abnormal genes or cell subsets for adopting corresponding targeted therapy to improve the prognosis of AL patients. In addition， the combination of transcriptomics technology with other omics technologies can monitor the multi?omics changes of AL from different levels， and more comprehensively analyze the molecular mechanism of the occurrence and development of AL. With the continuous application of RNA?seq technology， it will provide new precise targets and clinical strategies for the treatment of AL.
Key words： transcriptomics; acute leukemia; RNA?sequencing technology; gene fusion
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