目的 探究火针治疗膝关节骨关节炎患者的临床疗效及对骨关节炎指数（WOMAC）量表评分、视觉模拟评分（VAS）、肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）的影响。 方法 选取2021年7月至2022年2月就诊于广州中医药大学第一附属医院和重庆市中医院针灸科门诊的90例膝关节骨关节炎患者为研究对象，按随机数字表法分为火针观察组45例和普通针刺对照组45例，每周治疗3次，隔日治疗1次，治疗周期为4周。观察各临床疗效、WOMAC评分、VAS评分、血清IL-1β、TNF-α水平。 结果 观察组总有效率为88.89%，优于对照组（66.67%）（P < 0.05）。两组患者的WOMAC评分、VAS评分、有效率、IL-1β、TNF-α在治疗前后都差异有统计学意义（P < 0.01），且观察组较对照组治疗效果更优（P < 0.05）。所有患者治疗期间未发生不良事件。 结论 火针治疗膝关节骨关节炎能够显著缓解疼痛、提高关节活动度且安全可靠，其机制可能与下调血清IL-1β和TNF-α水平有关。

Objective To investigate the clinical efficacy of fire acupuncture in treating patients with knee osteoarthritis and its effects on osteoarthritis index （WOMAC） scale scores， visual analog （VAS） scores， tumor necrosis factor-α （TNF-α） and interleukin-1β （IL-1β）. Methods A total of 90 patients with knee osteoarthritis who visited the outpatient department of acupuncture and moxibustion of the First Affiliated Hospital of Guangzhou University of Chinese Medicine and Chongqing Traditional Chinese Medicine Hospital from July 2021 to February 2022 were selected as the research objects， and were divided into 45 cases in the observation group and 45 cases in the control group， according to the randomized number table method， and were treated three times a week （once every other day） for a 4-week treatment period. The WOMAC score， VAS score， serum IL-1β and TNF-α levels of the two groups were compared. Results The cure rate of the treatment group was 88.89%， which was better than that of the control group （66.67%） （P < 0.05）. The cure rate of the treatment group was 88.89%， which was better than that of the control group （66.67%） （P < 0.05）. On the other hand， that were significant differences in serum IL-1β， serum TNF-α， WOMAC score， VAS score， effective rate， between the two groups before and after treatment （P < 0.05）， and the effect of fire acupuncture observation group was better than that of ordinary acupuncture control group （P < 0.05）. No adverse safety events occurred in all patients during treatment. There were significant statistical differences in WOMAC score， VAS score， effective rate， IL-1β and TNF-α between the two groups before and after treatment （P < 0.01）， and the effect of observation group was better than that of control group （P < 0.05）. No adverse safety events occurred in all patients during treatment. Conclusion Fire acupuncture treatment for knee osteoarthritis can significant relieve pain， improve joint mobility and is safe and reliable， and its mechanism may be related to the dowm-regulated of serum IL-1β and TNF-α levels.