收稿日期: 2023-06-28
网络出版日期: 2023-12-11
基金资助
天津自然科学基金重点项目(21JCZDJC00550)
Correlation between sdLDL⁃C， CXCL12 and CVD in diabetic patients
目的 探讨血清小而密低密度脂蛋白胆固醇（sdLDL-C）以及CXC型趋化因子配体12（CXCL12）水平与心血管疾病（CVD）的相关性。 方法 选取2021年6月至2022年9月期间在医院接受治疗的糖尿病患者256例作为糖尿病组，根据患者是否合并CVD将其分为心血管疾病组和非心血管疾病组。并与健康志愿者（对照组）比较各组的血清sdLDL-C以及CXCL12水平，分析糖尿病患者并发CVD的危险因素，分析sdLDL-C、CXCL12及联合检测对糖尿病患者并发CVD的诊断价值。 结果 糖尿病组的血清sdLDL-C、CXCL12水平高于对照组（P < 0.05）。心血管疾病组的病程、BMI、LDL-C以及血清sdLDL-C、CXCL12水平均高于非心血管疾病组（P < 0.05）。经多因素logistic回归分析显示，sdLDL-C、CXCL12均为糖尿病患者并发CVD的独立影响因素（P < 0.05）。血清sdLDL-C、CXCL12联合检测的敏感度、特异度高于单一检测。 结论 糖尿病患者血清sdLDL-C以及CXCL12水平升高是并发CVD的独立危险因素，且二者的联合检测对于糖尿病并发CVD具有较高的诊断价值。
关键词： 糖尿病; 小而密低密度脂蛋白胆固醇; CXC型趋化因子配体12; 动脉粥样硬化性心血管疾病
马丽娜 , 曹振华 , 杨冰 . 小而密低密度脂蛋白胆固醇、CXC型趋化因子配体12与糖尿病患者并发心血管疾病的相关性[J]. 实用医学杂志, 2023 , 39(22) : 2953 -2957 . DOI: 10.3969/j.issn.1006-5725.2023.22.016
Objective To investigate the correlation between serum levels of small dense low density lipoprotein-cholesterol （sdLDL-C） and chemokine CXC motifligand12 （CXCL12） and diabetes mellitus with cardiovascular disease（CVD）. Methods A total of 256 diabetic patients treated in our hospital between June 2021 and September 2022 were selected as the diabetic group. The patients were grouped according to whether they had combined CVD or not. And the serum sdLDL-C as well as CXCL12 levels of each group were compared with healthy volunteers. Risk factors for the complication of CVD in diabetic patients were analyzed. To analyze the diagnostic value of sdLDL-C， CXCL12 and combined test for diabetic patients with complicated CVD. Results Serum sdLDL-C and CXCL12 levels were higher in the diabetes group than in the control group （P < 0.05）. The duration of disease， BMI， LDL-C， and serum sdLDL-C and CXCL12 levels were higher in the cardiovascular disease group than in the non-cardiovascular disease group （P < 0.05）. A multifactorial logistic regression analysis showed that sdLDL-C and CXCL12 were independent risk factors for the complication of CVD in diabetic patients （P < 0.05）. The sensitivity and specificity of serum sdLDL-C and CXCL12 combined test were higher than that of single test. Conclusion Elevated serum sdLDL-C and CXCL12 levels in patients with diabetes mellitus are independent risk factors for the complication of CVD， and the combination of these two tests has a high diagnostic value for diabetes mellitus with CVD.
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