收稿日期: 2023-07-11
网络出版日期: 2023-11-15
基金资助
国家自然科学基金资助项目(82160547);云南省科技厅-昆明医科大学应用基础研究联合专项资金资助项目(202201AC070524)
Research progress of predictive biomarkers for immune⁃related adverse events
Received date: 2023-07-11
Online published: 2023-11-15
邓俊 , 王均 , 高嫦娥 , 陈晓 , 史明霞 . 免疫检查点抑制剂毒性预测生物标志物的研究进展[J]. 实用医学杂志, 2023 , 39(20) : 2561 -2565 . DOI: 10.3969/j.issn.1006-5725.2023.20.001
In the era of cancer immunotherapy， with the release of more clinical trial results， the use of ICIs is more and more widely， but about 40% of these patients will experience irAEs， even some patients with fatal irAEs， early identification of irAEs can reduce irAEs related deaths and medical costs， and biomarkers are an important indicator of early identification of toxic reaction caused by ICIs. We review the latest progress in predicting biomarkers of irAEs， guiding the study of more convenient and fast predictors or predictive models through the combing of biomarkers， ultimately serving clinical work.
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