收稿日期: 2023-05-28
网络出版日期: 2023-09-27
基金资助
广东省基础与应用基础研究基金(2021B1515130004)
Research progress in the regulation of allergic asthma by dendritic cells
Received date: 2023-05-28
Online published: 2023-09-27
张芸蔓 , 黄功华 , 王妍妍 . 树突状细胞在过敏性哮喘发病中的作用及机制研究新进展[J]. 实用医学杂志, 2023 , 39(17) : 2280 -2284 . DOI: 10.3969/j.issn.1006-5725.2023.17.023
Allergic asthma is a chronic inflammatory airway disease characterized by over-activation of T helper 2 （Th2） cells in response to harmless air allergens. With high incidence and relapse rates， allergic asthma severely affects the life quality of patients. Dendritic cell （DC） plays important roles in initiating and maintaining Th2-mediated immune response during allergic asthma development，but the mechanism remains unclear. Therefore， it is important to study the function and underlying mechanism of DC in the pathogenesis of allergic asthma. We summarize the latest progress of immunometabolism， cytokines， and epigenetics in regulating DC function and DC-mediated Th2 immune responses， to direct the pathogenesis of allergic asthma. Further understanding the mechanisms by which DC regulates allergic asthma will provide new strategies for the treatment of allergic asthma.
Key words： dendritic cell; allergic asthma; immunoregulation
| 1 | STERN J， PIER J， LITONJUA A A. Asthma epidemiology and risk factors ［J］. Semin Immunopathol， 2020， 42（1）： 5-15. |
| 2 | ANDREA M， SUSANNA B， FRANCESCA N， et al. The emerging role of type 2 inflammation in asthma ［J］. Expert Rev Clin Immunol， 2021， 17（1）： 63-71. |
| 3 | TJOTA M Y， SPERLING A I. Distinct dendritic cell subsets actively induce Th2 polarization ［J］. Curr Opin Immunol， 2014， 31： 44-50. |
| 4 | HAN M， HU R， MA J， et al. Fas Signaling in Dendritic Cells Mediates Th2 Polarization in HDM-Induced Allergic Pulmonary Inflammation ［J］. Front Immunol， 2018， 9： 3045. |
| 5 | HAN M， MA J， OUYANG S， et al. The kinase p38alpha functions in dendritic cells to regulate Th2-cell differentiation and allergic inflammation ［J］. Cell Mol Immunol， 2022， 19（7）： 805-819. |
| 6 | CONEJERO L， KHOUILI S C， MARTINEZ-CANO S， et al. Lung CD103+ dendritic cells restrain allergic airway inflammation through IL-12 production ［J］. JCI Insight， 2017，2（10）：e90420. |
| 7 | ARDAIN A， MARAKALALA M J， LESLIE A. Tissue-resident innate immunity in the lung ［J］. Immunology， 2020， 159（3）： 245-256. |
| 8 | CHAIRAKAKI A D， SARIDAKI M I， PYRILLOU K， et al. Plasmacytoid dendritic cells drive acute asthma exacerbations ［J］. J Allergy Clin Immunol， 2018， 142（2）： 542-556 e512. |
| 9 | DEMEDTS I K， BRACKE K R， MAES T， et al. Different roles for human lung dendritic cell subsets in pulmonary immune defense mechanisms ［J］. Am J Respir Cell Mol Biol， 2006， 35（3）： 387-393. |
| 10 | EL-GAMMAL A， OLIVERIA J P， HOWIE K， et al. Allergen-induced Changes in Bone Marrow and Airway Dendritic Cells in Subjects with Asthma ［J］. Am J Respir Crit Care Med， 2016， 194（2）： 169-177. |
| 11 | AZID N A， AHMAD S， BOER J C， et al. A profile of TNFR2（+） regulatory T cells and CD103（+） dendritic cells in the peripheral blood of patients with asthma ［J］. Hum Immunol， 2020， 81（10-11）： 634-643. |
| 12 | SUN S， GU Y， WANG J， et al. Effects of Fatty Acid Oxidation and Its Regulation on Dendritic Cell-Mediated Immune Responses in Allergies： An Immunometabolism Perspective ［J］. J Immunol Res， 2021， 2021： 7483865. |
| 13 | KRATCHMAROV R， VIRAGOVA S， KIM M J， et al. Metabolic control of cell fate bifurcations in a hematopoietic progenitor population ［J］. Immunol Cell Biol， 2018， 96（8）： 863-871. |
| 14 | YIN X， ZENG W， WU B， et al. PPARalpha Inhibition Overcomes Tumor-Derived Exosomal Lipid-Induced Dendritic Cell Dysfunction ［J］. Cell Rep， 2020， 33（3）： 108278. |
| 15 | ZHANG C， YUE C， HERRMANN A， et al. STAT3 Activation-Induced Fatty Acid Oxidation in CD8（+） T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth ［J］. Cell Metab， 2020， 31（1）： 148-161 e145. |
| 16 | MALINARICH F， DUAN K， HAMID R A， et al. High mitochondrial respiration and glycolytic capacity represent a metabolic phenotype of human tolerogenic dendritic cells ［J］. J Immunol， 2015， 194（11）： 5174-5186. |
| 17 | HSIEH M H， JAN R L， WU L S， et al. Lactobacillus gasseri attenuates allergic airway inflammation through PPARgamma activation in dendritic cells ［J］. J Mol Med （Berl）， 2018， 96（1）： 39-51. |
| 18 | NIEVES W， HUNG L Y， ONISKEY T K， et al. Myeloid-Restricted AMPKalpha1 Promotes Host Immunity and Protects against IL-12/23p40-Dependent Lung Injury during Hookworm Infection ［J］. J Immunol， 2016， 196（11）： 4632-4640. |
| 19 | GAUVREAU G M， SEHMI R， AMBROSE C S， et al. Thymic stromal lymphopoietin： its role and potential as a therapeutic target in asthma ［J］. Expert Opin Ther Targets， 2020， 24（8）： 777-792. |
| 20 | HUANG L， ZHANG X， WANG M， et al. Exosomes from Thymic Stromal Lymphopoietin-Activated Dendritic Cells Promote Th2 Differentiation through the OX40 Ligand ［J］. Pathobiology， 2019， 86（2-3）： 111-117. |
| 21 | NGUYEN K D， VANICHSARN C， NADEAU K C. TSLP directly impairs pulmonary Treg function： association with aberrant tolerogenic immunity in asthmatic airway ［J］. Allergy Asthma Clin Immunol， 2010， 6（1）： 4. |
| 22 | HONG H， LIAO S， CHEN F， et al. Role of IL-25， IL-33， and TSLP in triggering united airway diseases toward type 2 inflammation ［J］. Allergy， 2020， 75（11）： 2794-2804. |
| 23 | LI Y， WANG W， LV Z， et al. Elevated Expression of IL-33 and TSLP in the Airways of Human Asthmatics In Vivo： A Potential Biomarker of Severe Refractory Disease ［J］. J Immunol， 2018， 200（7）： 2253-2262. |
| 24 | WANG W， AN G， LI Y， et al. IL-33 amplifies airways inflammation in a murine surrogate of asthma putatively via activation of dendritic cells ［J］. Cell Immunol， 2021， 366： 104395. |
| 25 | PENG B， SUN L， ZHANG M， et al. Role of IL-25 on Eosinophils in the Initiation of Th2 Responses in Allergic Asthma ［J］. Front Immunol， 2022， 13： 842500. |
| 26 | XU M， DONG C. IL-25 in allergic inflammation ［J］. Immunol Rev， 2017， 278（1）： 185-191. |
| 27 | HONGJIA L， CAIQING Z， DEGAN L， et al. IL-25 promotes Th2 immunity responses in airway inflammation of asthmatic mice via activation of dendritic cells ［J］. Inflammation， 2014， 37（4）： 1070-1077. |
| 28 | ZECH A， AYATA C K， PANKRATZ F， et al. MicroRNA-155 modulates P2R signaling and Th2 priming of dendritic cells during allergic airway inflammation in mice ［J］. Allergy， 2015， 70（9）： 1121-1129. |
| 29 | TANG H， JIANG H， ZHENG J， et al. MicroRNA-106b regulates pro-allergic properties of dendritic cells and Th2 polarisation by targeting early growth response-2 in vitro ［J］. Int Immunopharmacol， 2015， 28（2）： 866-874. |
| 30 | HUANG L， WANG M， CHEN Z， et al. MiR-138 regulates dendritic cells mediated Th2-type immune response by regulating the OX40L expression in asthma ［J］. Int J Clin Exp Pathol， 2017， 10（11）： 10979-10988. |
| 31 | KIDD C D， THOMPSON P J， BARRETT L， et al. Histone Modifications and Asthma. The Interface of the Epigenetic and Genetic Landscapes ［J］. Am J Respir Cell Mol Biol， 2016， 54（1）： 3-12. |
| 32 | KASINATH V， BECK C， SAUER P， et al. JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications ［J］. Science， 2021，371（6527）：eabc3393. |
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