收稿日期: 2023-06-09
网络出版日期: 2023-09-27
基金资助
贵州省卫生健康委科学技术基金项目(Gzwkj2021-353)
Changes in serum sB7⁃H3 and CX3CR1 levels in patients with irreversible pulpitis and their clinical significance
Received date: 2023-06-09
Online published: 2023-09-27
目的 检测不可复性牙髓炎患者可溶性B7-H3（sB7-H3）、CX3C趋化因子受体1（CX3CR1）水平变化，探讨二者在预后中的评估价值。 方法 选取104例不可复性牙髓炎患者为病例组，其中急性牙髓炎52例、慢性牙髓炎52例，根据治疗结果分为预后好组83例和预后差组21例；选同期体检健康者101例为健康组。采用酶联免疫吸附法检测血清sB7-H3、CX3CR1水平。 结果 病例组血清sB7-H3、CX3CR1水平高于健康组（P < 0.05）。急性牙髓炎患者血清sB7-H3、CX3CR1水平高于慢性牙髓炎患者（P < 0.05）。预后差组治疗前后血清sB7-H3、CX3CR1水平高于预后好组（P < 0.05）；血清sB7-H3、CX3CR1水平不同时间、组间及交互作用比较，差异有统计学意义（P < 0.05）。预后差组病情为急性的患者比例高于预后好组（P < 0.05）。sB7-H3、CX3CR1是不可复性牙髓炎患者预后差的独立影响因素（P < 0.05）。 结论 不可复性牙髓炎患者血清sB7-H3、CX3CR1水平升高，二者可能成为评估不可复性牙髓炎病情及治疗效果的重要指标。
关键词： 不可复性牙髓炎; 可溶性B7-H3; CX3C趋化因子受体1; 预后
袁媛园 , 潘露 , 周绍兰 . 不可复性牙髓炎患者血清可溶性B7-H3、CX3趋化因子受体1水平变化及其临床意义[J]. 实用医学杂志, 2023 , 39(17) : 2221 -2224 . DOI: 10.3969/j.issn.1006-5725.2023.17.012
Objective To detect the changes of soluble B7-H3 （sB7-H3） and CX3C chemokine receptor 1 （CX3CR1） levels in patients with irreducible pulpitis and explore their prognostic value. Methods A total of 104 patients with irreversible pulpitis involved in the study， including 52 cases of acute pulpitis and 52 cases of chronic pulpitis. According to the treatment results， 83 cases with good prognosis were assigned as one group and 21 cases with poor prognosis as another group. Meanwhile， another 101 healthy individuals who underwent physical examination during the same period were enrolled as the health group. Enzyme-linked immunosorbent assay was applied to detect serum levels of sB7-H3 and CX3CR1. Results The serum levels of sB7-H3 and CX3CR1 in the case group were higher than those in the healthy group （P < 0.05）. The serum levels of sB7-H3 and CX3CR1 in the acute pulpitis group were higher than those in the chronic pulpitis group （P < 0.05）. The serum levels of sB7-H3 and CX3CR1 in the poor prognosis group before and after treatment were higher than those in the good prognosis group （P < 0.05） and the serum levels of sB7-H3 and CX3CR1 were statistically significant different across different time points， between the groups and in terms of interactions （P < 0.05）. The proportion of patients with acute conditions in the poor prognosis group was higher than that in the good prognosis group （P < 0.05）. SB7-H3 and CX3CR1 were independent risk factors for the poor prognosis in the patients （P < 0.05）. Conclusion The levels of serum sB7-H3 and CX3CR1 in patients with irreversible pulpitis are elevated. They may become important indicators for evaluating the conditions and treatment effectiveness of irreversible pulpitis.
Key words： irreversible pulpitis; soluble B7-H3; CX3C chemokine receptor 1; prognosis
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