收稿日期: 2023-05-10
网络出版日期: 2023-09-26
基金资助
国家自然科学基金项目(82260503);云南省基础研究专项重点项目(202301AS070077);云南省“兴滇英才支持计划”名医(XDYC-MY-2022-0034);技术创新人才培养对象项目(202105AD160063);“春城计划”青年拔尖人才(C201914014)
Bidirectional regulation of tumor associated neutrophils and their role in urothelial bladder cancer： a literature review
Received date: 2023-05-10
Online published: 2023-09-26
邓凯 , 杨萌 , 张琳 , 钱俊安 , 史云强 , 王春晖 . 肿瘤相关中性粒细胞的双向调控作用及其在膀胱尿路上皮癌中的研究进展[J]. 实用医学杂志, 2023 , 39(16) : 2142 -2147 . DOI: 10.3969/j.issn.1006-5725.2023.16.022
Urothelial bladder cancer （UBC） is one of the most common malignant tumors in urology， and its occurrence and progression are closely related to the tumor microenvironment （TME）. Tumor-associated neutrophils （TAN）， as an important type of immune cells in TME， have been proven to have anti-tumor or pro-tumor regulatory effects on various tumors， which are related to their heterogeneity and plasticity. The study on TAN′s bidirectional regulation may provide new targets for tumor treatment. This article reviews the current status of TAN′s bidirectional regulation research by searching recent literature， and summarizes its research progress in UBC.
| 1 | HEDRICK C C， MALANCHI I. Neutrophils in cancer： heterogeneous and multifaceted ［J］. Nat Rev Immunol， 2022， 22（3）： 173-187. |
| 2 | JAILLON S， PONZETTA A， DI MITRI D， et al. Neutrophil diversity and plasticity in tumour progression and therapy ［J］. Nat Rev Cancer， 2020， 20（9）： 485-503. |
| 3 | KIM R， HASHIMOTO A， MARKOSYAN N， et al. Ferroptosis of tumour neutrophils causes immune suppression in cancer ［J］. Nature， 2022， 612（7939）： 338-46. |
| 4 | ZHANG W， SHEN Y， HUANG H， et al. A Rosetta Stone for Breast Cancer： Prognostic Value and Dynamic Regulation of Neutrophil in Tumor Microenvironment ［J］. Front Immunol， 2020， 11： 1779. |
| 5 | BINNEWIES M， ROBERTS E W， KERSTEN K， et al. Understanding the tumor immune microenvironment （TIME） for effective therapy ［J］. Nat Med， 2018， 24（5）： 541-550. |
| 6 | SHAUL M E， FRIDLENDER Z G. Tumour-associated neutrophils in patients with cancer ［J］. Nat Rev Clin Oncol， 2019， 16（10）： 601-620. |
| 7 | HIRSCHHORN D， BUDHU S， KRAEHENBUEHL L， et al. T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants ［J］. Cell， 2023， 186（7）： 1432-47.e17. |
| 8 | MAHIDDINE K， BLAISDELL A， MA S， et al. Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils ［J］. J Clin Invest， 2020， 130（1）： 389-403. |
| 9 | GERSHKOVITZ M， CASPI Y， FAINSOD-LEVI T， et al. TRPM2 Mediates Neutrophil Killing of Disseminated Tumor Cells ［J］. Cancer Res， 2018， 78（10）： 2680-2690. |
| 10 | MATLUNG H L， BABES L， ZHAO X W， et al. Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis ［J］. Cell Rep， 2018， 23（13）： 3946-3959.e6. |
| 11 | PONZETTA A， CARRIERO R， CARNEVALE S， et al. Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors ［J］. Cell， 2019， 178（2）： 346-360.e24. |
| 12 | WANG W， GUO Y， ZHONG J， et al. The clinical significance of microvascular invasion in the surgical planning and postoperative sequential treatment in hepatocellular carcinoma ［J］. Sci Rep， 2021， 11（1）： 2415. |
| 13 | 吴玲红， 周敏， 卢瑶，等. 中性粒细胞/淋巴细胞比值及其变化值对肝细胞癌介入术后急性肝功能恶化风险的预测价值 ［J］. 实用医学杂志， 2023， 39（6）： 713-718. |
| 14 | 万梦园， 刘书娟， 刘晶晶，等. 术前系统免疫炎症指数与胰腺癌患者预后的关系 ［J］. 实用医学杂志， 2021， 37（19）： 2482-2486. |
| 15 | WCULEK S K， BRIDGEMAN V L， PEAKMAN F， et al. Early Neutrophil Responses to Chemical Carcinogenesis Shape Long-Term Lung Cancer Susceptibility ［J］. iScience， 2020， 23（7）： 101277. |
| 16 | BUTIN-ISRAELI V， BUI T M， WIESOLEK H L， et al. Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing ［J］. J Clin Invest， 2019， 129（2）： 712-726. |
| 17 | RICE C M， DAVIES L C， SUBLESKI J J， et al. Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression ［J］. Nat Commun， 2018， 9（1）： 5099. |
| 18 | XU W， DONG J， ZHENG Y， et al. Immune-Checkpoint Protein VISTA Regulates Antitumor Immunity by Controlling Myeloid Cell-Mediated Inflammation and Immunosuppression ［J］. Cancer Immunol Res， 2019， 7（9）： 1497-1510. |
| 19 | MIZUNO R， KAWADA K， ITATANI Y， et al. The Role of Tumor-Associated Neutrophils in Colorectal Cancer ［J］. Int J Mol Sci， 2019， 20（3）：529. |
| 20 | 徐希， 张振声， 许传亮. 中性粒细胞胞外诱捕网在膀胱癌中的研究进展 ［J］. 癌症进展， 2022， 20（16）： 1632-1634，1651. |
| 21 | HASSAN W A， ELBANNA A K， NOUFAL N， et al. Significance of tumor-associated neutrophils， lymphocytes， and neutrophil-to-lymphocyte ratio in non-invasive and invasive bladder urothelial carcinoma ［J］. J Pathol Transl Med， 2023，57（2）：88-94. |
| 22 | ULERI A， HURLE R， CONTIERI R， et al. Combination of AST to ALT and neutrophils to lymphocytes ratios as predictors of locally advanced disease in patients with bladder cancer subjected to radical cystectomy： Results from a single-institutional series ［J］. Urologia， 2022， 89（3）： 363-370. |
| 23 | LIU K， ZHAO K， WANG L， et al. The prognostic values of tumor-infiltrating neutrophils， lymphocytes and neutrophil/lymphocyte rates in bladder urothelial cancer ［J］. Pathol Res Pract， 2018， 214（8）： 1074-1080. |
| 24 | LI D X， WANG X M， FENG D C， et al. Neutrophil-to-lymphocyte ratio （NLR） during induction is a better predictor than preoperative NLR in non-muscle-invasive bladder cancer receiving Bacillus Calmette-GuéRin ［J］. Asian J Surg， 2023， 46（3）： 1348-1351. |
| 25 | ZHANG Q， LIU S， WANG H， et al. ETV4 Mediated Tumor-Associated Neutrophil Infiltration Facilitates Lymphangiogenesis and Lymphatic Metastasis of Bladder Cancer ［J］. Adv Sci （Weinh）， 2023，10（11）： e2205613. |
| 26 | XIANG Z， ZHOU Q， ZENG H， et al. Intratumoral CCR5+ neutrophils identify immunogenic subtype muscle-invasive bladder cancer with favorable prognosis and therapeutic responses ［J］. Oncoimmunology， 2020， 9（1）： 1802176. |
| 27 | MANDELLI G E， MISSALE F， BRESCIANI D， et al. Tumor Infiltrating Neutrophils Are Enriched in Basal-Type Urothelial Bladder Cancer ［J］. Cells， 2020， 9（2）：291. |
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