肝细胞癌（hepatocellular carcinoma，HCC）是常见恶性肿瘤之一，其高发病率、高病死率、低生存率是 HCC 在我国流行病学上呈现出的基本特征。研究发现磷脂酶 A2（phospholipase A2，PLA2）参与磷脂消化代谢、免疫防御和信号传导等复杂进程，且积极参与肝组织炎症反应、肝细胞存活、增殖及凋亡等作用，参与 HCC 发生发展过程。本文介绍了 PLA2 在 HCC 的发生、发展过程中所起作用特点，指出了 PLA2 可作为HCC 的药物研发和临床防治的新思路和药物靶点。 

Hepatocellular carcinoma （HCC） is one of the most common malignant tumors， and its high morbidity， high mortality rate， and low survival rate are the basic features of the epidemiology of HCC in China. It has been found that phospholipase A2（PLA2） is involved in the complex processes of phospholipid digestion and metabolism， immune defense and signaling， and actively participates in the inflammatory response of liver tissue， hepatocyte survival， proliferation and apoptosis， and the process of hepatocellular carcinogenesis and development. This paper introduces the role of PLA2 in the development of HCC and points out that PLA2 can be used as a new idea and drug target for drug development and clinical control of HCC.