肠道微生物群与机体长期共生，不仅参与构成肠道屏障，还可以通过产生宿主生理所必需 的维生素和其他产物来维持机体的新陈代谢。自噬是一种用于维持稳态的细胞分解代谢过程，它在所有组织的基础水平上起作用。本文将从调节肠道微生物群时自噬的变化，以及自噬改变时肠道微生物群的变化进行阐述，为疾病的治疗提供更多的研究方向。 

The intestinal microbiome has a long⁃term symbiosis with the body，not only participating in the formation of the intestinal barrier，but also maintaining the body′ s metabolism by producing vitamins and other products necessary for host physiology. Autophagy is a cellular catabolic process used to maintain homeostasis，and it functions at a fundamental level in all tissues. In this review，we will elaborate the changes of autophagy when regulating intestinal microbiome and the changes of intestinal microbiome when autophagy changes，so as to pro⁃ vide more research directions for the treatment of diseases.