隧道纳米管（tunneling nanotubes，TNTs）是主要以肌动蛋白为骨架形成的细胞间管道结构， 相当于连接细胞之间的桥梁。作为新发现的细胞间通信机制，TNTs 能够实现细胞间长距离的通信与物质 的定向运输，介导细胞器、核酸、小分子蛋白等物质在细胞间转移。TNTs 借助自身的通讯与运输功能影响 神经退行性疾病、癌症等疾病的发生发展，同时也为相关疾病的治疗提供一些新思路、新靶点。本篇综述 详细介绍了TNTs 的形态结构、形成机制、形成相关调节因子、功能特性以及生理学意义。

Tunneling nanotubes（TNTs）are intercellular pipe structures formed mainly by actin，which are equivalent to bridges connecting cells. As a newly discovered mechanism of intercellular communication， TNTs realize long⁃distance communication and directional transport of substances between cells. TNTs mediate the transfer of organelles，nucleic acids，small molecular proteins and other substances between cells. TNTs use communication and transportation functions to influence the occurrence and development of neurodegenerative diseases，tumors，cancers and other diseases，and provide some new ideas and new targets for the treatment of related diseases. This review introduces the morphological structure，formation mechanism，formation related regu⁃ latory factors，functions and physiological significance of TNTs.