目的 探究吲哚布芬联合氯吡格雷对急性冠脉综合征患者血管内皮功能、炎性因子、氧化应 激的影响。方法 本研究回顾性选择2020年6月至2022年3月在河北中医学院第二附属医院行经皮冠状 动脉介入治疗（PCI）治疗的急性冠脉综合征患者156例作为研究对象，以数字表法将其分为两组，各78例。 观察组给予吲哚布芬联合氯吡格雷治疗，对照组给予氯吡格雷治疗。比较患者疗效及各项指标，同时记录 不良反应情况。结果 观察组疗效优于对照组（P < 0.05）；治疗后两组患者血管内皮功能指标较治疗前均 显著改善（P < 0.05），且观察组血管内皮生长因子（VEGF）高于对照组（P < 0.05），而内皮素⁃1（ET⁃1）低于对照组（P < 0.05）；治疗后患者炎症因子较治疗后均下降（P < 0.05），且观察组超敏C反应蛋白（hs⁃CRP）、肿瘤 坏死因子-α（TNF⁃α）水平均显著低于对照组（P < 0.05）；治疗后患者氧化应激指标较治疗前均改善（P < 0.05），且观察组一氧化氮（NO）及一氧化氮合酶（tNOS）指标均显著高于对照组（P < 0.05），而丙二醛低于对 照组（P < 0.05）；治疗后观察组患者心血管不良事件发生率与出血率较对照组低（P < 0.05）；两组不良反应 率比较，差异无统计学意义（P > 0.05）。结论 应用吲哚布芬联合氯吡格雷治疗急性冠脉综合征患者疗效 确切，能有效改善各项指标，降低不良事件发生率，缓解炎症，出血率低，安全性良好，值得深入推广。 

Objective To investigate the effects of indobufen combined with clopidogrel on vascular endo⁃ thelial function，inflammatory factors，and oxidative stress in patients with acute coronary syndrome. Methods This study retrospectively selected 156 patients as the research object who had acute coronary syndrome and underwent PCI in our hospital from June 2020 to March 2022. They were divided into two groups by the number table method， with78 patients in each group. The observation group was treated with indobufen combined with clopidogrel，and the control group was treated with clopidogrel. The efficacy and indicators of patients were compared，and the adverse reactions were recorded. Result The therapeutic effect of the observation group was better than that of the control group（P < 0.05）；After treatment，the endothelial function indicators of both groups of patients were signif⁃ icantly improved compared to before treatment（P < 0.05），and the VEGF level in the observation group was higher than that in the control group（P < 0.05），while ET⁃1 was lower than that in the control group（P < 0.05）；After treatment，the inflammatory factors in patients decreased compared to those after treatment（P < 0.05），and the observation group showed hs CRP and TNF⁃α levels. These levels were significantly lower than those of the control group（P < 0.05）；After treatment，the oxidative stress indicators of patients improved compared to before treat⁃ ment（P < 0.05），and the NO and tNOS indicators in the observation group were significantly higher than those in the control group（P < 0.05），while the malondialdehyde levels were lower than those in the control group（P < 0.05）； The incidence of cardiovascular adverse events and bleeding in the observation group after treatment was lower than that in the control group（P < 0.05）；There was no statistically significant difference in the incidence of adverse reactions between the two groups（P > 0.05）. Conclusion The application of indobufen combined with clopidogrel in the treatment of acute coronary syndrome patients has a definite therapeutic effect that can effectively improve various indicators，reduce the incidence of adverse events，and alleviate inflammation and therefore lead to a low bleeding rate，and good safety，which is worthy of further promotion.