2型糖尿病伴慢性牙周炎患者的口腔菌群微环境研究进展&nbsp;

王佩佩 华飞 黄霞 葛峻沂 赵璐 顾敏

doi:10.3969/j.issn.1006⁃5725.2023.10.023

实用医学杂志 >

2023 , Vol. 39 >Issue 10: 1320 - 1324

DOI: https://doi.org/10.3969/j.issn.1006⁃5725.2023.10.023

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2型糖尿病伴慢性牙周炎患者的口腔菌群微环境研究进展

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苏州大学附属第三医院（常州市第一人民医院）1 口腔科，2 内分泌科（江苏常州 213003）； 3 暨南大学口腔医学院（广州 510624）

网络出版日期: 2023-05-25

基金资助

常州市科技计划应用基础研究（编号：CJ20210092）；常州市卫生健康青苗人才（编号：CZQM2020025）；2022 年苏州大学研究生课程思政示范课程专项（编号：23124400）；2022 年苏州大学研究生教育改革成果奖培育项目（编号：5832001222）；常州市“十四五”卫生健康高层次人才培养工程拔尖人才（编号： KY20221388）；常州市卫健委青年人才项目（编号：QN202004）

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Research progress of oral microenvironment in patients with type 2 diabetes mellitus and chronic periodon⁃ titis

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Department of Stomatology，Affili⁃ ated Third Hospital of Soochow University，The First People′s Hospital of Changzhou city，Changzhou 213003， China

Online published: 2023-05-25

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摘要

2 型糖尿病是患病率较高的内分泌系统疾病；慢性牙周炎是发病率较高的口腔常见病。多项研究表明两者在临床症状上密切相关。近几年学者通过微生物层面的实验，逐渐揭示2型糖尿病、慢性牙周炎患者的口腔菌群情况，试图探索 2 型糖尿病伴慢性牙周炎患者的疾病规律，但是尚未有文献对 2 型糖尿病伴慢性牙周炎患者口腔菌群的多样性、特异性作一系统介绍。本文从 2 型糖尿病与慢性牙周炎的临床关联性入手，阐述二者与口腔菌群的关系，依据微生物学迅速发展更新的实验方法，对 2 型糖尿病伴慢性牙周炎患者的口腔菌群微环境研究进展进行综述，旨为后续深入研究指明方向。

关键词： 菌群; 2型糖尿病; 慢性牙周炎; 龈下菌斑; 唾液

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王佩佩华飞黄霞葛峻沂赵璐顾敏 . 2型糖尿病伴慢性牙周炎患者的口腔菌群微环境研究进展 [J]. 实用医学杂志, 2023 , 39(10) : 1320 -1324 . DOI: 10.3969/j.issn.1006⁃5725.2023.10.023

Abstract

Type 2 diabetes mellitus（T2DM）is an endocrine disease with high prevalence，and chronic periodontitis（CP）is a common oral disease with high incidence. A number of studies have shown that the two are closely related in clinical manifestations. In recent years，researchers have gradually revealed the status of oral microbiota in patients with T2DM and CP through experiments at the microbial level，trying to explore the law of disease in patients with T2DM and CP. However，there is no systematic introduction to the diversity and specificity of oral microbiota in patients with T2DM and CP. Based on the clinical correlation，this article elaborates the relationship between the two diseases and oral microbiota，and further reviews the research progress of the oral microenvironment of T2DM patients with CP according to the rapid development and update of experimental methods in microbiology，so as to provide the direction for further research.

Key words： ; "> microflora; type 2 diabetes mellitus; chronic periodontitis; subgingival plaque; saliva

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