色素上皮衍生因子（PEDF）是一种 50 kDa 分泌型糖蛋白，具有多种生物学效应和生理活性， 包括抗血管生成、抗肿瘤和神经营养活性等。从1987年PEDF被发现以来，许多研究证实PEDF或PEDF的 多肽片段具有治疗多种疾病的潜力，尤其是伴有新生血管形成、神经损伤、肿瘤等病理改变的疾病。角膜 疾病常出现新生血管浸润、炎性反应、神经损伤等，目前 PEDF 在角膜疾病治疗中的应用也逐渐成为研究 热点，现将此方面的研究进展进行综述。

Pigment epithelium derived factor（PEDF）is a type of 50 kDa secretory glycoprotein with a variety of biological effects and physiological activities，including anti ⁃angiogenesis，anti ⁃tumor and neurotrophic activities. Since the discovery of PEDF in 1987，many studies have confirmed that PEDF or its polypeptide frag⁃ ments have the potential to treat a variety of diseases，especially those with pathological changes such as neovascu⁃ larization，nerve injury and tumor. Corneal diseases often accompanied with neovascular infiltration，inflammatory reaction，and nerve damage. At present，the application of PEDF in the treatment of corneal diseases has gradually become a research hotspot. This paper reviews the research progress in this area.